Mitochondria form networks that continually remodel and adapt to carry out their cellular function. The mitochondrial network is remodeled through changes in mitochondrial morphology, number, and distribution within the cell. Mitochondrial dynamics depend directly on fission, fusion, shape transition, and transport or tethering along the cytoskeleton. Over the past several years, many of the mechanisms underlying these processes have been uncovered. It has become clear that each process is precisely and contextually regulated within the cell. Here, we discuss the mechanisms regulating each aspect of mitochondrial dynamics, which together shape the network as a whole.

线粒体形成网络，不断重塑和适应以执行其细胞功能。线粒体网络通过细胞内线粒体形态、数量和分布的变化来重塑。线粒体动力学直接取决于裂变、融合、形状转变以及沿细胞骨架的运输或束缚。在过去的几年里，这些过程背后的许多机制已经被揭示。很明显，细胞内的每个过程都受到精确且具体的调节。在这里，我们讨论调节线粒体动力学各个方面的机制，这些机制共同塑造了整个网络。