Background

Balance impairment is a hallmark of Parkinson's disease with dramatic effects for patients (e.g. falls). Its assessment is thus of paramount importance. The aim of this work is to assess which measures from the instrumented Timed Up and Go test (recorded with inertial sensors) are valid balance measures in Parkinson's disease and evaluate their responsiveness to rehabilitation.

Methods

The Mini-BESTest (a criterion-standard balance measure) and the instrumented Timed Up and Go test (with inertial sensors secured to the trunk) were administered to 20 Parkinson's disease patients before and after inpatient rehabilitation (median [IQR]; 76.5 [8.25] years; 5 females; Hoehn and Yahr stage: 2.5 [0.5]). 81 parameters from the instrumented Timed Up and Go test were evaluated. Multiple factor analysis (a variant of principal component analysis for repeated measurements) and effect sizes were used to assess validity and responsiveness, respectively.

Findings

Only the first component of the multiple factor analysis correlated with the Mini-BESTest, and 21 measures from the instrumented Timed Up and Go test had large loadings on this component. However, only three of these 21 measures also directly correlated with the Mini-BESTest (trunk angular velocities from sit-to-walk and turning; r = 0.46 to 0.50, P = 0.021 to 0.038). Sit-to-walk angular velocity showed greater responsiveness than the Mini-BESTest, while turning showed slightly less.

Interpretation

Angular velocities from the turning and sit-to-walk phases of the Timed Up and Go test are valid balance measures in Parkinson's disease and are also responsive to rehabilitation.

中文翻译：

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仪器化的定时和走行测试中的转弯和步行测量可返回帕金森氏病动态平衡的有效和响应性测量

背景

平衡障碍是帕金森氏病的标志，会对患者产生巨大影响（例如跌倒）。因此，对其评估至关重要。这项工作的目的是评估仪器化的“定时加走”测试（用惯性传感器记录）中的哪些措施是帕金森氏病的有效平衡措施，并评估其对康复的反应能力。

方法

在住院康复前后，对20名帕金森氏病患者进行了Mini-BESTest（标准-标准平衡测量）和仪器化的Timed Up and Go测试（将惯性传感器固定在躯干上）（中位数[IQR]； 76.5 [8.25]）年； 5名女性； Hoehn和Yahr阶段：2.5 [0.5]）。评估了通过仪器测试的Timed Up and Go测试的81个参数。多因素分析（一种用于重复测量的主成分分析的变体）和效应量分别用于评估有效性和响应性。

发现

只有多因素分析的第一个组件与Mini-BESTest相关，而仪器化的Timed Up and Go测试中的21个量度对该组件有很大的负担。但是，在这21个度量中，只有三个也与Mini-BESTest直接相关（从坐到走和转弯的躯干角速度；r  = 0.46至0.50，P  = 0.021至0.038）。静坐行走的角速度显示出比Mini-BESTest更高的响应速度，而转弯时显示出的响应速度略有下降。

解释

Timed Up and Go测试的转弯和从坐到走阶段的角速度是帕金森氏病的有效平衡措施，并且对康复也有反应。