A novel green solvent, CO₂-expanded ethanol (CXE), was employed to extract oil from grape seeds, which is one of the main by-products generated by the grape-processing industry. The optimum extraction conditions were obtained by response surface methodology (RSM) coupled with Box-Behnken design (BBD): a pressure of 7.4 MPa, a temperature of 314 K and a CO₂ mole fraction of 0.3. The highest oil yield of 13.6 % by CXE extraction was equivalent to or even higher than that obtained with conventional methods, including organic solvent and supercritical CO₂ extraction. In terms of reducing solvent consumption and extraction time, the CXE-based process was superior than the conventional methods. CXE oil contained 87.5 % total unsaturated fatty acids, especially linoleic acid was up to 75.5 %, presenting a higher antioxidant capacity.

一种新型的绿色溶剂，CO ₂膨胀的乙醇（CXE），用于从葡萄籽中提取油，葡萄籽是葡萄加工工业产生的主要副产物之一。最佳萃取条件是通过响应表面方法（RSM）与Box-Behnken设计（BBD）结合获得的：压力为7.4 MPa，温度为314 K，CO ₂摩尔分数为0.3。通过CXE萃取获得的最高油产率为13.6％，与甚至包括有机溶剂和超临界CO ₂在内的常规方法所获得的产率相当甚至更高。萃取。在减少溶剂消耗和提取时间方面，基于CXE的方法优于常规方法。CXE油中总不饱和脂肪酸含量为87.5％，尤其是亚油酸高达75.5％，具有更高的抗氧化能力。