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Mechanically strong and bioactive carbon fiber-SiC nanowire-hydroxyapatite-pyrolytic carbon composites for bone implant application
Ceramics International ( IF 5.1 ) Pub Date : 2021-02-01 , DOI: 10.1016/j.ceramint.2020.09.184
Fei Zhao , Leilei Zhang , Yao Guo , Hongchao Sheng , Pengxiang Zhang , Yixin Zhang , Qian Li , Hongyi Yang , Sergey V. Mikhalovsky

Abstract Carbon fiber-SiC nanowire-hydroxyapatite-pyrolytic carbon composites (CHS) composed of carbon fiber, hydroxyapatite (HA), SiC nanowires (SiCnws) and pyrolytic carbon (PyC) were prepared by sol-gel, heat treating, electrochemical deposition (ECD) and isothermal chemical vapor infiltration (ICVI) for bone implant application. The morphology, microstructure and the composition of CHS were investigated by X-ray diffraction (XRD), scanning electron microscopy (SEM), energy dispersive X-ray spectroscopy (EDS) and transmission electron microscopy (TEM). The mechanical properties of CHS were tested and compared with the traditional bone implant materials. The in-vitro bioactivity was evaluated by testing the cell morphology, cell proliferation and cell differentiation. The results show that SiCnws and HA are distributed uniformly inside the CHS. SiCnws are attached on the carbon fibers. The diameter of the SiCnws is around 250 nm and the length is more than 100 μm. HA could grow on the surface of both SiCnws and carbon fibers, forming a brush shape. The flexural strength, shear strength, out-of-plane and in-of-plane compressive strength of CHS are 127 MPa, 90 MPa, 169 MPa and 213 MPa, respectively. The elastic modulus of CHS is 7.2 GPa. The mechanical properties of CHS are similar to those of cortical bone. In-vitro cell test shows that CHS has excellent cell proliferation and cell differentiation. CHS possessing good mechanical and biological performances may have potential to be applied for bone implant materials.

中文翻译:

用于骨植入物的机械强度和生物活性碳纤维-SiC 纳米线-羟基磷灰石-热解碳复合材料

摘要 以碳纤维、羟基磷灰石(HA)、碳化硅纳米线(SiCnws)和热解碳(PyC)组成的碳纤维-SiC纳米线-羟基磷灰石-热解碳复合材料(CHS)通过溶胶-凝胶、热处理、电化学沉积(ECD)制备) 和用于骨植入物的等温化学蒸汽渗透 (ICVI)。通过X射线衍射(XRD)、扫描电子显微镜(SEM)、能量色散X射线光谱(EDS)和透射电子显微镜(TEM)研究了CHS的形貌、微观结构和组成。测试了 CHS 的机械性能,并与传统的骨植入材料进行了比较。通过测试细胞形态、细胞增殖和细胞分化来评估体外生物活性。结果表明 SiCnws 和 HA 在 CHS 内均匀分布。SiCnws 附着在碳纤维上。SiCnws 的直径约为 250 nm,长度超过 100 μm。HA 可以在 SiCnws 和碳纤维的表面生长,形成刷状。CHS的弯曲强度、剪切强度、面外和面内压缩强度分别为127 MPa、90 MPa、169 MPa和213 MPa。CHS的弹性模量为7.2 GPa。CHS 的力学性能与皮质骨相似。体外细胞试验表明,CHS具有优良的细胞增殖和细胞分化能力。具有良好机械和生物学性能的 CHS 有可能应用于骨植入材料。HA 可以在 SiCnws 和碳纤维的表面生长,形成刷状。CHS的弯曲强度、剪切强度、面外和面内压缩强度分别为127 MPa、90 MPa、169 MPa和213 MPa。CHS的弹性模量为7.2 GPa。CHS 的力学性能与皮质骨相似。体外细胞试验表明,CHS具有优良的细胞增殖和细胞分化能力。具有良好机械和生物学性能的 CHS 有可能应用于骨植入材料。HA 可以在 SiCnws 和碳纤维的表面生长,形成刷状。CHS的弯曲强度、剪切强度、面外和面内压缩强度分别为127 MPa、90 MPa、169 MPa和213 MPa。CHS的弹性模量为7.2 GPa。CHS 的力学性能与皮质骨相似。体外细胞试验表明,CHS具有优良的细胞增殖和细胞分化能力。具有良好机械和生物学性能的 CHS 有可能应用于骨植入材料。体外细胞试验表明,CHS具有优良的细胞增殖和细胞分化能力。具有良好机械和生物学性能的 CHS 有可能应用于骨植入材料。体外细胞试验表明,CHS具有优良的细胞增殖和细胞分化能力。具有良好机械和生物学性能的 CHS 有可能应用于骨植入材料。
更新日期:2021-02-01
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