Extensive phytochemical analysis of the CHCl₃-soluble part of an ethanolic extract of branches and twigs of Broussonetia papyrifera led to the isolation of fourteen compounds, including a novel 5,11-dioxabenzo[b]fluoren-10-one derivative named broussofluorenone C (12). The isolated compounds 1–14 were characterized based on their NMR and HRMS data, and examined for their anti-inflammatory activities in LPS-stimulated THP-1 cells as well as for their cellular antioxidant effects. Compounds 7–10 and 12 showed inhibitory effects on NF-κB/AP-1 activation and compounds 7–9 were subsequently confirmed to suppress the secretion of both IL-1β and TNF-α in LPS-stimulated THP-1 cells more significantly than the prednisone used as a positive control. In the CAA assay, compound 10 exhibited the greatest antioxidant effect, greater than that of the quercetin used as a positive control. The results show possible beneficial effects and utilization of B. papyrifera wood in the treatment of inflammatory diseases as well as oxidative stress.

的氯仿的广泛的植物化学分析₃的分支和细枝的乙醇提取物的可溶部分构树导致14个化合物，包括一种新颖的5,11-二氧杂苯并[隔离b ]芴-10-酮衍生物命名broussofluorenone C（12）。在分离的化合物1 - 14基于它们的NMR和HRMS数据进行了表征，并在检查其抗炎活性LPS刺激的THP-1细胞，以及用于它们的细胞的抗氧化作用。化合物7 – 10和12对NF-κB/ AP-1的活化具有抑制作用，化合物7 – 9随后证实，与强的松用作阳性对照相比，LPS刺激的THP-1细胞中IL-1β和TNF-α的分泌抑制作用更为显着。在CAA分析中，化合物10表现出最大的抗氧化作用，大于用作阳性对照的槲皮素。结果表明，纸莎草（B. papyrifera）木材在治疗炎症和氧化应激方面可能具有有益效果。