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Synthesis of non-nucleoside anti-viral cyclopropylcarboxacyl hydrazones and initial anti-HSV-1 structure-activity relationship studies.
Bioorganic & Medicinal Chemistry Letters ( IF 2.5 ) Pub Date : 2020-09-19 , DOI: 10.1016/j.bmcl.2020.127559 James McNulty 1 , Chanti Babu Dokuburra 1 , Leonardo D'Aiuto 2 , Matthew Demers 2 , Lora McClain 2 , Paolo Piazza 2 , Kelly Williamson 2 , Wenxiao Zheng 2 , Vishwajit L Nimgaonkar 2
中文翻译：
非核苷类抗病毒环丙基羧酰腙的合成及抗 HSV-1 构效关系的初步研究。
更新日期：2020-09-25
Bioorganic & Medicinal Chemistry Letters ( IF 2.5 ) Pub Date : 2020-09-19 , DOI: 10.1016/j.bmcl.2020.127559 James McNulty 1 , Chanti Babu Dokuburra 1 , Leonardo D'Aiuto 2 , Matthew Demers 2 , Lora McClain 2 , Paolo Piazza 2 , Kelly Williamson 2 , Wenxiao Zheng 2 , Vishwajit L Nimgaonkar 2
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The synthesis of a lead anti-viral cyclopropyl carboxy acyl hydrazone 4F17 (5) and three sequential arrays of structural analogues along with the initial assessment and optimization of the antiviral pharmacophore against the herpes simplex virus type 1 (HSV-1) are reported.
中文翻译：
非核苷类抗病毒环丙基羧酰腙的合成及抗 HSV-1 构效关系的初步研究。
报道了先导抗病毒环丙基羧基酰基腙 4F17 ( 5 ) 和结构类似物的三个序列阵列的合成，以及针对 1 型单纯疱疹病毒 (HSV-1) 的抗病毒药效团的初步评估和优化。
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