The treatment of chronic wounds is a major challenge in regenerative medicine, and angiogenesis is known to be critical for chronic wound healing. Hot springs with temperature in the range of 30–45 °C can promote blood circulation, and some hot spring elements including iron and silicon are also known to be active in promoting angiogenesis. Inspired by the hot spring function, we designed a novel bioactive photothermal hydrogel with “hot spring effect” based on fayalite (FA) and N, O-carboxymethyl chitosan (NOCS), which releases bioactive ions and has heating function to create hot ion environment in wound area. The hot spring-mimetic hydrogel showed significant enhancement of angiogenesis and chronic wound healing in vivo due to the in situ heating through photothermal effect combined with the bioactive ions (Fe²⁺ and SiO₄⁴⁻) released from the hydrogel. It is further confirmed that the synergetic effect of the mild heating and bioactive ions on angiogenesis was mainly because of the activation of different angiogenic factors and signaling pathways. Our study suggests that the hot spring-mimetic approach may be an effective strategy to design bioactive materials for promoting angiogenesis and tissue regeneration.

慢性伤口的治疗是再生医学的主要挑战，并且已知血管生成对于慢性伤口愈合至关重要。温度范围在30–45°C的温泉可以促进血液循环，一些铁和硅等温泉元素还可以促进血管生成。受温泉功能的启发，我们设计了一种基于铁橄榄石（FA）和N，O-羧甲基壳聚糖（NOCS）的具有“温泉效应”的新型生物活性光热水凝胶，它释放生物活性离子并具有加热功能，从而创造了热离子环境。在伤口处。模拟温泉水凝胶由于原位显示体内显着增强血管生成和慢性伤口愈合通过光热效应与从水凝胶中释放出的生物活性离子（Fe ²⁺和SiO ₄ ^4-）结合而加热。进一步证实，温和的加热和生物活性离子对血管生成的协同作用主要是由于不同的血管生成因子和信号传导途径的激活。我们的研究表明，模拟温泉的方法可能是设计用于促进血管生成和组织再生的生物活性材料的有效策略。