The intraperitoneal cysticercosis model with the Taenia crassiceps ORF strain in female BALB/cAnN mice has been widely used to study the immune response in cysticercosis. During early infection (2 weeks), the host develops a non-permissive Th1 response, whereas during late infection (8 weeks), molecules from the cysticerci induce a Th2 response that is permissive to parasite growth. The modulation of the Th2 response is induced by molecules excreted/secreted by the larval stage of the parasite. However, there is limited information regarding the response of cysticerci to the mouse immunological environment during infection. The proteomic profiles in T. crassiceps ORF cysticerci when faced with the mouse Th1 and Th2 responses were analyzed through two-dimensional gel electrophoresis (2DE), and the differential expression of proteins was evaluated. Thirteen proteins, whose differential expression varied between 70% and 100%, were selected randomly. Protein identification by MALDI-TOF MS and BLAST showed that the proteins were related to folding, signaling, enzymatic activities, cell-movement regulation, cell-cell interactions, motility, carbohydrate metabolism, detoxification, and redox regulation processes. Notably, some of the proteins can act as antigenic-protective molecules and elicit a weak Th1 response; however, most are involved in the avoidance of the immune system, which leads to a Th2 response, or apoptosis. The findings indicate the process by which T. crassiceps cysticerci responds based on the host environment and provides novel insights into the mechanism by which this facilitates its establishment and persistence in the mouse. Furthermore, these proteins could be used as targets for drug and vaccine development.

雌性BALB / cAnN小鼠中带有Taenia crassiceps ORF株的腹膜内囊尾ice病模型已被广泛用于研究囊尾rc病的免疫反应。在早期感染（2周）期间，宿主会产生非允许的Th1反应，而在晚期感染（8周）期间，来自囊虫的分子会诱导Th2反应，该反应允许寄生虫生长。Th2反应的调节是由寄生虫的幼虫阶段分泌/分泌的分子诱导的。但是，关于感染期间囊尾er对小鼠免疫环境的反应的信息有限。T. crassiceps的蛋白质组学概况通过二维凝胶电泳（2DE）分析了ORF囊性小鼠面对小鼠Th1和Th2反应的情况，并评估了蛋白质的差异表达。随机选择差异表达在70％至100％之间的13种蛋白质。通过MALDI-TOF MS和BLAST鉴定蛋白质表明，这些蛋白质与折叠，信号传导，酶活性，细胞运动调节，细胞间相互作用，运动性，碳水化合物代谢，排毒和氧化还原调节过程有关。值得注意的是，某些蛋白质可以充当抗原保护分子并引起较弱的Th1反应。然而，大多数涉及避免免疫系统，从而导致Th2反应或细胞凋亡。研究结果表明了T. crassiceps cysticerci基于宿主环境做出反应，并提供了新的见解，从而促进了它在小鼠中的建立和持久性。此外，这些蛋白质可以用作药物和疫苗开发的靶标。