Flavonoids are now considered as an indispensable component in a variety of nutraceutical and pharmaceutical applications. Most recent researches have focused on the health aspects of flavonoids for humans. Especially, different flavonoids have been investigated for their potential antiviral activities, and several natural flavonoids exhibited significant antiviral properties both in vitro and in vivo. This review provides a survey of the literature regarding the evidence for antiviral bioactivities of natural flavonoids, highlights the cellular and molecular mechanisms of natural flavonoids on viruses, and presents the details of most reported flavonoids. Meanwhile, future perspectives on therapeutic applications of flavonoids against viral infections were discussed.

类黄酮现在被认为是各种营养保健品和药物应用中不可或缺的成分。最近的研究主要集中在类黄酮对人类健康的影响上。特别是，不同的黄酮类化合物的潜在抗病毒活性已被研究，几种天然黄酮类化合物在体外和体内均表现出显着的抗病毒特性。本综述对有关天然类黄酮抗病毒生物活性证据的文献进行了调查，强调了天然类黄酮对病毒的细胞和分子机制，并介绍了大多数报道的类黄酮的详细信息。同时，讨论了黄酮类化合物抗病毒感染的治疗应用的未来前景。