The present analytical survey explores different aspects of hydrolytic degradation of drug dosage forms (DF) based on polylactides, homopolymers of lactic acid (PLA) and copolymers of lactic and glycolic acids (PLGA). The study includes various scientific data from multiple sources describing the effect of the PLGA nanocarrier hydrolytic degradation rate on the profile of drug release from the DFs intended for intravenous and intramuscular administration, including micro- and nanoparticles, and implants. The following aspects are explored in the review: design of experiments aimed at studying the hydrolytic degradation kinetics of PLGA carriers; commonly employed analytical methods; interpretation of the mechanism of PLGA-based DF hydrolytic degradation; factors that influence the hydrolytic degradation rate of PLGA drug carriers as part of DFs; interrelation between the processes of polymer carrier hydrolytic degradation and drug substance release from the PLGA-based DFs.

中文翻译：

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聚乳酸药物载体的水解降解在开发微米级和纳米级聚乳酸类药物剂型中的作用

本分析调查探讨了基于聚丙交酯、乳酸均聚物 (PLA) 以及乳酸和乙醇酸共聚物 (PLGA) 的药物剂型 (DF) 水解降解的不同方面。该研究包括来自多个来源的各种科学数据，这些数据描述了 PLGA 纳米载体水解降解率对用于静脉内和肌肉内给药的 DF（包括微米和纳米颗粒以及植入物）的药物释放曲线的影响。综述探讨了以下几个方面：旨在研究PLGA载体水解降解动力学的实验设计；常用的分析方法；基于PLGA的DF水解降解机理的解释；影响作为DFs一部分的PLGA药物载体水解降解率的因素；