Over the past decades, circadian rhythm has drawn a great attention in cardiovascular diseases. The expressions of rhythm genes fluctuate in accordance with the diurnal changes of vascular physiology, which highlights the pivotal effect of vascular clock. Recent researches show that the circadian clock can directly regulate the synthetic and secretory function of endothelial cells and phenotypic switch of vascular smooth muscle cells to adjust vascular relaxation and contraction. Importantly, dysfunction of vascular cells is involved in vascular calcification. Secretion of osteogenic cytokines and calcified vesicles in the vessel, osteogenic phenotype switch of vascular smooth muscle cells are all implicated in the calcification process. Moreover, circadian rhythm disorder can lead to abnormal hormone secretion, oxidative stress, inflammatory reaction, and autophagy, all of which should not be ignored in vascular calcification. Vascular senescence is another pathogenetic mechanism in vascular calcification. Accelerated vascular senescence may act as an important intermediate factor to promote vascular calcification in circadian rhythm disorders. In this review, we elaborate the potential effect of circadian rhythm disorder in vascular calcification and try to provide a new direction in the prevention of vascular calcification.

在过去的几十年中，昼夜节律引起了心血管疾病的极大关注。节奏基因的表达根据血管生理的昼夜变化而波动，这突出了血管时钟的关键作用。最近的研究表明，生物钟可以直接调节内皮细胞的合成和分泌功能以及血管平滑肌细胞的表型转换，从而调节血管的舒张和收缩。重要的是，血管细胞功能障碍与血管钙化有关。血管中成骨细胞因子和钙化小泡的分泌，血管平滑肌细胞的成骨表型转换均与钙化过程有关。此外，昼夜节律障碍可能导致荷尔蒙分泌异常，氧化应激，炎症反应和自噬，在血管钙化中不容忽视。血管衰老是血管钙化的另一种致病机制。昼夜节律紊乱中加速的血管衰老可能是促进血管钙化的重要中间因素。在这篇综述中，我们阐述了昼夜节律障碍在血管钙化中的潜在作用，并试图为预防血管钙化提供新的方向。