Abstract

The titanium dioxide nanoparticles (TiO₂NPs) were synthesized by the aqueous extract from P. djamor. The UV–Vis spectrum of TiO₂NPs showed maximum absorption at 345 nm and the XRD pattern reflects peaks at 2θ value of 27.51°, 36.16°, 41.31°, 54.37°, 56.68°, 62.80° and 69.04° can be indexed to the (110), (101), (111), (211), (220), (204) and (301) were confirm the presence of TiO₂NPs. The FT-IR spectrum of TiO₂NPs showed a peak at 3432, 1631, 1400, 1109, and 619 cm⁻¹. The SEM and HRTEM analysis revealed the spherical shape size and EDAX pattern confirmed the purity of TiO₂NPs. The particle size of TiO₂NPs found to be 31 nm and the zeta potential showed 16.4mV. Antibacterial activity TiO₂NPs recorded the highest zone of inhibition 33 ± 0.2 mm, 32 ± 0.4 mm and 32 ± 0.1 mm against P. fluorescens, S. aureus and C. diphtheriae. Further, the anticancer activity of TiO₂NPs showed 9.08–64.71% at 6.25–100 µg/ml concentration against A549 cancer cells. The larvicidal activities of TiO₂ NPs on IVth instar larvae of Ae. aegypti and Cx quinquefasciatus results showed LC₅₀ (5.88 and 4.84 mg/l) and LC₉₀ (22.80 and 19.33 mg/l) in better effect. The multi biological activity of TiO₂NPs was utilized in future pharmacological application.

Graphic Abstract

中文翻译：

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食用菌提取物生物合成TiO 2纳米粒子的研究：蚊杀幼虫，组织病理学，抗菌和抗癌作用

摘要

通过茉莉假单胞菌的水提物合成二氧化钛纳米粒子（TiO ₂ NPs）。TiO ₂ NPs的UV-Vis光谱显示在345 nm处具有最大吸收，并且XRD图谱反映了2θ值为27.51°，36.16°，41.31°，54.37°，56.68°，62.80°和69.04°的峰。 （110），（101），（111），（211），（220），（204）和（301）证实了TiO ₂ NP的存在。TiO ₂ NP的FT-IR光谱在3432、1631、1400、1109和619cm ^-1处显示峰。SEM和HRTEM分析表明球形尺寸和EDAX图案证实了TiO ₂ NP的纯度。TiO ₂的粒径发现NP为31nm，ζ电位显示为16.4mV。抗菌活性TiO ₂ NPs对荧光假单胞菌，金黄色葡萄球菌和白喉衣原体的抑制作用最高，分别为33±0.2 mm，32±0.4 mm和32±0.1 mm 。此外，TiO ₂ NPs在6.25–100 µg / ml浓度下对A549癌细胞的抗癌活性显示为9.08–64.71％。TiO ₂ NPs对Ae第四龄幼虫的杀幼虫活性。埃及伊蚊和西番莲Cx quinquefasciatus结果显示LC ₅₀（5.88和4.84 mg / l）和LC ₉₀（22.80和19.33 mg / l）效果更好。TiO的多生物活性在未来的药理应用中使用了_2种NP。

图形摘要