Titanium oxide nanoparticles modified with D-(+)-mannose were obtained. In the process of their formation, they were conjugated with an active substance (tadalafil). The physicochemical properties of the obtained products were assessed, and the size and electrokinetic potential were determined using a dynamic light scattering technique. X-ray diffractometry was applied in order to define the crystalline properties, and Fourier-transform infrared spectroscopy was used to confirm the formation of the desired products. It was possible to obtain TiO₂ coated with D-(+)-mannose. The average size of nanoparticles was between 230 and 268 nm. The release of the active substance from the product over a time period of three hours was assessed against the reference material, which was not modified by D-(+)-mannose. The results indicate that covering titanium oxide nanoparticles with the modifying substance favours a slower rate of release for the active substance, which is the desired effect from a pharmacological point of view. The releasing of active substance from modified products was even 68% slower than that from the reference product. These modified titanium oxides are promising materials that may have found an application as drug carriers.

Graphic Abstract

中文翻译：

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D-（+）-甘露糖修饰的氧化钛基纳米颗粒的制备及其作为潜在药物载体的性能研究

获得了用D-（+）-甘露糖修饰的二氧化钛纳米颗粒。在其形成过程中，将它们与活性物质（他达拉非）偶联。评估获得的产物的理化性质，并使用动态光散射技术确定其大小和电动势。应用X射线衍射仪确定晶体性质，并使用傅立叶变换红外光谱法确认所需产物的形成。有可能获得TiO ₂用D-（+）-甘露糖包被。纳米颗粒的平均尺寸在230至268nm之间。针对未经过D-（+）-甘露糖修饰的参考物质，评估了活性物质在三个小时内从产品中的释放。结果表明，用改性物质覆盖二氧化钛纳米粒子有利于活性物质的较慢释放速率，这是从药理学角度来看所需的效果。从改性产品中释放的活性物质甚至比参考产品中的释放慢68％。这些改性的二氧化钛是很有希望的材料，可能已被用作药物载体。

图形摘要