Albumin, the most abundant and long-lived serum protein, exhibits novel features as a carrier that can greatly enhance the pharmacological action of therapeutic payloads. Besides passive trafficking by enhanced permeability and retention effect, albumin has been shown to accumulate within the tumor environment or inflamed tissues by receptor-mediated active transport, lending itself to being a promising scaffold for targeted drug delivery. Albumin has recently been found to be a scavenger for amyloid-β with the potential to treat neurodegenerative diseases. The hydrophobic binding pockets, conjugatable thiol residue, and surface-exposed N- and C-termini in albumin inherently serve as useful spots for carrying various kinds of peptidyl and non-peptidyl drugs. Beyond its long-standing role as a half-life extender, albumin is emerging as a versatile drug carrier to aid numerous therapeutic agents that have poor pharmacokinetics, targetability, solubility, and instability in vivo.

白蛋白是最丰富和寿命最长的血清蛋白，具有新颖的功能，可大大增强治疗有效载荷的药理作用。除了通过增强的通透性和保留作用来进行被动转运外，白蛋白还通过受体介导的主动转运在肿瘤环境或发炎的组织中积聚，使其成为有希望的靶向药物输送支架。最近发现白蛋白是淀粉样β的清除剂，具有治疗神经退行性疾病的潜力。白蛋白中的疏水性结合口袋，可结合的硫醇残基以及表面暴露的N和C末端固有地充当携带各种肽基和非肽基药物的有用位点。除了长期发挥半衰期延长剂的作用外，体内。