In this work, a CMOS based optical read-out system for biomarker on immunostrips detection is presented. For the proposed system, a CMOS integrated circuit containing an on-chip photodiode is designed in standard 180 nm UMC CMOS Technology. The system also contains cost-effective 3D Printed structures for holding both IC and the sample immunostrip together. The proposed system can be operated in two modes (1) light reflectance and (2) light transmittance. In the system, a laser with a wavelength of 637 nm is applied to the CMOS IC through immunostrip. Photovoltaic and photoconductive measurements are carried out for each mode on a custom Gluten biomarker immunostrip. Sensing operation of the biomarker is successfully realized with optical powers from 5 mW to 8 mW. Biomaterial density on the immunostrip is sensed and images of the biomarker with varying intensities are constructed from the measurements. Feasibility of the system for low power biomarker sensing applications is demonstrated.

在这项工作中，提出了一种基于CMOS的光学读出系统，用于免疫条检测上的生物标记。对于建议的系统，采用标准180 nm UMC CMOS技术设计了包含片上光电二极管的CMOS集成电路。该系统还包含具有成本效益的3D打印结构，用于将IC和样品免疫条固定在一起。所提出的系统可以以两种模式操作：（1）光反射率和（2）光透射率。在该系统中，通过免疫带将波长为637 nm的激光应用于CMOS IC。在定制的面筋生物标记免疫条上针对每种模式进行光伏和光电导测量。通过5 mW至8 mW的光功率成功实现了生物标记物的传感操作。感测免疫条上的生物材料密度，并根据测量结果构建具有不同强度的生物标志物图像。证明了该系统在低功率生物标志物传感应用中的可行性。