Vanadium is an ultratrace element. The transition metal vanadium, widely existed in the environment and exhibits various biological and physiological effects in the human body, yet with no presently known specific physiological function in mammals. sodium orthovanadate (SOV) is a kind of vanadium compound. SOV has shown promising antineoplastic activity in several human cancers. But the effects of SOV on acute promyelocytic leukemia are still unknown. In this study, for the first time, we found that SOV could inhibit proliferation, induce G2/M cell cycle arrest and apoptosis, and could inhibit autophagy of acute leukemia cell lines in vitro. Thus, our findings suggest that SOV could effectively suppress the growth of acute leukemia HL60 cells and HL60/A cells through the regulations of proliferation, cell cycle, apoptosis and autophagy, and thus may act as a potential therapeutic agent in acute promyelocytic leukemia treatment.

中文翻译：

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原钒酸钠在体外抑制急性白血病HL60细胞和HL60 / A细胞的生长。

钒是一种超痕量元素。过渡金属钒广泛存在于环境中，在人体中表现出各种生物学和生理作用，但目前在哺乳动物中尚无已知的特定生理功能。原钒酸钠（SOV）是一种钒化合物。SOV在几种人类癌症中显示出令人鼓舞的抗肿瘤活性。但是SOV对急性早幼粒细胞白血病的影响尚不清楚。在这项研究中，我们首次发现SOV可以抑制增殖，诱导G2 / M细胞周期停滞和凋亡，并可以在体外抑制急性白血病细胞系的自噬。因此，我们的研究结果表明SOV可以通过增殖，细胞周期，凋亡和自噬的调控来有效抑制急性白血病HL60细胞和HL60 / A细胞的生长，