Polyphenol scaffolds in tissue engineering,Materials Horizons

当前位置： X-MOL 学术 › Mater. Horiz. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Polyphenol scaffolds in tissue engineering
Materials Horizons ( IF 12.2 ) Pub Date : 2020-09-17 , DOI: 10.1039/d0mh01317j
Xueqian Zhang ₁ , Zhan Li , Peng Yang , Gaigai Duan , Xianhu Liu , Zhipeng Gu , Yiwen Li

Affiliation

Polyphenols are a class of ubiquitous compounds distributed in nature, with fascinating inherent biocompatible, bioadhesive, antioxidant, and antibacterial properties. The unique polyphenolic structures based on catechol or pyrogallol moieties allow for strong non-covalent interactions (e.g., multiple hydrogen bonding, electrostatic, and cation–π interactions) as well as covalent interactions (e.g., Michael addition/Schiff-base reaction, radical coupling reaction, and dynamic coordination interactions with boronate or metal ions). This review article provides an overview of the polyphenol-based scaffolds including the hydrogels, films, and nanofibers that have emerged from chemical and functional signatures during the past years. A full description of the structure–function relationships in terms of their utilization in wound healing, bone regeneration, and electroactive tissue engineering is also carefully discussed, which may pave the path towards the rational design and facile preparation of next-generation polyphenol scaffolds for tissue engineering applications.

中文翻译：

组织工程中的多酚支架

多酚是一类分布于自然界的普遍存在的化合物，具有迷人的内在生物相容性、生物粘附性、抗氧化性和抗菌性。基于儿茶酚或连苯三酚部分的独特多酚结构允许强非共价相互作用（例如，多重氢键、静电和阳离子-π 相互作用）以及共价相互作用（例如，迈克尔加成/席夫碱反应，自由基偶联反应，以及与硼酸盐或金属离子的动态配位相互作用）。这篇综述文章概述了基于多酚的支架，包括在过去几年中从化学和功能特征中出现的水凝胶、薄膜和纳米纤维。还详细讨论了结构-功能关系在伤口愈合、骨再生和电活性组织工程中的应用，这可能为下一代组织多酚支架的合理设计和简便制备铺平道路工程应用。

更新日期：2020-09-17

点击分享查看原文

点击收藏

阅读更多本刊最新论文本刊介绍/投稿指南11