The Mt-HAP composites were achieved by combining layered montmorillonite (Mt) and hydroxyapatite (HAP) nanoparticles produced by in situ assembly technique. Amoxicillin (AMX) loading and release experiment proved that the synthetic Mt-HAP composites demonstrated high drug loading ability and pH-responsive sustained release property. The AMX load of original Mt was 18.5 mg g −1 , while that of Mt-HAP grew to 49.1 mg g −1 . Experiments in simulated gastric fluid (pH 1.2) release indicated that Mt drug carrier having a higher release rate of AMX within the initial 2 h. But after that, the drug release rate of AMX from Mt-HAP has a greater value (about 65% over 12 h) than that of Mt (about 50% over 12 h) because of the dissolution of HAP under acidic circumstance. However, the cumulative sustained release rate of Mt-HAP in simulated intestinal fluid (pH 6.8) over 12 h was only 30%, and the drug release amount of Mt was still about 49%. Compared to Mt@AMX, th...

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具有pH响应缓释特性的Mt-HAP药物载体的原位组装

Mt-HAP复合材料是通过组合通过原位组装技术生产的层状蒙脱土（Mt）和羟基磷灰石（HAP）纳米粒子获得的。阿莫西林（AMX）的负载和释放实验证明，合成的Mt-HAP复合材料具有较高的药物负载能力和pH响应的缓释性能。原始Mt的AMX负载为18.5 mg g -1，而Mt-HAP的AMX负载增长至49.1 mg g -1。模拟胃液（pH 1.2）释放的实验表明，Mt药物载体在最初的2小时内具有较高的AMX释放速率。但是在那之后，由于酸性环境中HAP的溶解，AMX从Mt-HAP的释药速率具有更大的价值（在12 h内约为65％），比在Mt-HAP的释药速率（12 h上约为50％）更大。然而，Mt-HAP在模拟肠液（pH 6.8）中经过12 h的累积缓释率仅为30％，而Mt的药物释放量仍约为49％。与Mt @ AMX相比，...