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Cytotoxic Prenyl and Geranyl Coumarins from the Stem Bark of Casimiroa edulis
Letters in Organic Chemistry ( IF 0.7 ) Pub Date : 2020-08-31 , DOI: 10.2174/1570178616666191019121437
Khun Nay Win Tun 1 , Nanik Siti Aminah 1 , Alfinda Novi Kristanti 1 , Rico Ramadhan 1 , Yoshiaki Takaya 2
Affiliation  

Phytochemical investigation of the methanolic extract of the stem bark of Casimiroa edulis afforded four coumarins. Various spectroscopic experiments were used to characterize the isolated coumarins. The structures were identified as auraptene (K-1), suberosin (K-2), 5-geranyloxypsoralen (bergamottin) (K-3), and 8-geranyloxypsoralen (K-4), based on the chemical and spectral analysis. Among these compounds, suberosin (K-2) and 5-geranyloxypsoralen (bergamottin) (K-3) were isolated for the first time from this genus, and auraptene (K-1) was isolated from this plant for the first time. Cytotoxicity of pure compound K-4 and sub-fraction MD-3 was evaluated against HeLa and T47D cell lines and moderate activity was found with an IC50 value in the range 17.4 to 72.33 μg/mL.



中文翻译:

食用木麻黄的茎皮中有细胞毒性的异戊二烯基和香叶基香豆素

对可食的卡西米亚(Casimiroa edulis)茎皮的甲醇提取物进行植物化学研究,得到了四个香豆素。各种光谱实验被用来表征分离出的香豆素。根据化学和光谱分析,该结构被鉴定为紫杉醇(K-1),亚油溶蛋白(K-2),5-香叶基氧补骨脂素(佛手柑)(K-3)和8-香叶基氧补骨脂素(K-4)。在这些化合物中,首次从该属中分离出亚eroosin(K-2)和5-香叶基氧补骨脂素(bergamottin)(K-3),并首次从该植物中分离出紫杉烷(K-1)。评估了纯化合物K-4和亚级分MD-3对HeLa和T47D细胞系的细胞毒性,发现中等活性,IC50值在17.4至72.33μg/ mL范围内。

更新日期:2020-08-31
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