We have successfully explored the potential MoO3 nanoparticles as a heterogeneous catalyst for the cyclocondensation of hydrazines/hydrazides with 1,3-dicarbonyl compound in aqueousalcoholic medium at room temperature. The present method has been developed using green chemistry measures and offers a range of N-substituted pyrazoles with moderate to excellent yields. Utilization of non-toxic catalyst, wide substrate scope and environmentally benign reaction medium are the important features of the developed protocol. Interestingly, MoO3 nanocatalyst can easily be recovered from the reaction mixture and showed excellent reusability with a modest change in product yield. We have reported herein the synthetic pathway with less disastrous effect in the atmosphere.

我们已经成功地探索了潜在的MoO3纳米颗粒作为多相催化剂在室温下在含水醇介质中与1,3-二羰基化合物进行肼/酰肼的环缩合反应。本方法是使用绿色化学方法开发的，并提供了一系列中等至极好的N-取代吡唑。利用无毒催化剂，广泛的底物范围和对环境无害的反应介质是所开发方案的重要特征。有趣的是，MoO3纳米催化剂可以轻松地从反应混合物中回收并显示出极好的可重复使用性，并且产品收率会有适度的变化。我们已经在本文中报道了在大气中具有较少灾难性影响的合成途径。