Composite nanoparticles composed of anionic phospholipid of 1,2-dipalmitoyl-sn-glycero-3-phosphorylglycerol (DPPG) and resveratrol (Res) were successfully prepared by mixing them in water and a subsequent heating/cooling process. Small-sized DPPG-Res nanoparticles (<60 nm) could be prepared by ultrasonic fragmentation. Upon addition of size-controlled fluorescently labeled Res (^FLRes) nanoparticles stabilized with DPPG (DPPG-^FLRes) to rat skin tissue, ^FLRes molecules infiltrated into the epidermis layer permeating stratum corneum.

中文翻译：

---

使用阴离子磷脂将小分子白藜芦醇纳米颗粒透皮递送至表皮。

通过将它们在水中混合并随后进行加热/冷却过程，成功地制备了由1,2-二棕榈酰基-sn-甘油-3-磷酸基甘油的阴离子磷脂（DPPG）和白藜芦醇（Res）组成的复合纳米颗粒。可以通过超声破碎制备小尺寸的DPPG-Res纳米颗粒（<60 nm）。向大鼠皮肤组织中添加用DPPG（DPPG- ^FL Res）稳定后的尺寸受控的荧光标记Res（^FL Res）纳米颗粒后，^FL Res分子渗透到渗透到角质层的表皮层中。