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Transdermal Delivery of Small-Sized Resveratrol Nanoparticles to Epidermis Using Anionic Phospholipids
Natural Product Communications ( IF 1.5 ) Pub Date : 2020-09-17 , DOI: 10.1177/1934578x20951443
Noriyuki Uchida 1 , Masayoshi Yanagi 2 , Kei shimoda 3 , Hiroki Hamada 2
Affiliation  

Composite nanoparticles composed of anionic phospholipid of 1,2-dipalmitoyl-sn-glycero-3-phosphorylglycerol (DPPG) and resveratrol (Res) were successfully prepared by mixing them in water and a subsequent heating/cooling process. Small-sized DPPG-Res nanoparticles (<60 nm) could be prepared by ultrasonic fragmentation. Upon addition of size-controlled fluorescently labeled Res (FLRes) nanoparticles stabilized with DPPG (DPPG-FLRes) to rat skin tissue, FLRes molecules infiltrated into the epidermis layer permeating stratum corneum.



中文翻译:

使用阴离子磷脂将小分子白藜芦醇纳米颗粒透皮递送至表皮。

通过将它们在水中混合并随后进行加热/冷却过程,成功地制备了由1,2-二棕榈酰基-sn-甘油-3-磷酸基甘油的阴离子磷脂(DPPG)和白藜芦醇(Res)组成的复合纳米颗粒。可以通过超声破碎制备小尺寸的DPPG-Res纳米颗粒(<60 nm)。向大鼠皮肤组织中添加用DPPG(DPPG- FL Res)稳定后的尺寸受控的荧光标记Res(FL Res)纳米颗粒后,FL Res分子渗透到渗透到角质层的表皮层中。

更新日期:2020-09-18
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