Introduction People with inflammatory bowel disease (IBD) are at increased risk of pneumonia and herpes zoster, yet other common infection types have not been explored. Anxiety and depression are more prevalent in IBD; however, the impact of these conditions on primary care healthcare use in IBD is not known. Methods and analysis We will perform two retrospective studies using a large English population-based primary care cohort to compare the following outcomes in people with IBD and matched controls: incident infections (Study 1) and prevalent mental health problems and healthcare use, overall and in those with and without mental health problems (Study 2). All adults registered with general practices contributing to Royal College of General Practitioners Research and Surveillance Centre database between 1 January 2014 and 1 January 2019 are eligible. Infection outcomes comprise the incidence of common infections (upper respiratory tract infections, pneumonia, acute bronchitis, influenza and influenza-like illnesses, skin infections, herpes simplex and herpes zoster infections, genital infections, urinary tract infections and gastrointestinal infections) and any viral infection. Mental health and healthcare use outcomes are: prevalence of depressive episodes; anxiety episodes; recurrent depression; rates of primary care and emergency secondary care visits; primary-care issued sick notes (reflecting time off work). Analyses will be adjusted for sociodemographic factors recorded in the primary care record. Discussion These studies will quantify the infection risk in IBD, the excess burden of anxiety and depression in a population-based IBD cohort, and the impact of mental health conditions on healthcare use and time off work. Greater understanding and awareness of infection risk and common mental health issues will benefit people with IBD and healthcare practitioners and will guide policy makers as allocation of resource may be guided by the real-world information produced by these studies. Trial registration number [NCT03836612][1]. Data may be obtained from a third party and are not publicly available. The RCGP RSC dataset is held securely at Oxford University and the University of Surrey and can be accessed by bone fide researchers. Approval is on a project-by-project basis (www.rcgp.org.uk/rsc). Ethical approval by an NHS Research Ethics Committee may be needed before any data release/other appropriate approval. Researchers wishing to directly analyse the patient-level pseudonymised data will be required to complete information governance training and work on the data from university secure servers. Patient-level data cannot be taken out of the secure network. [1]: /lookup/external-ref?link_type=CLINTRIALGOV&access_num=NCT03836612&atom=%2Febmental%2F24%2F2%2F82.atom

中文翻译：

---

炎症性肠病患者的常见感染、心理健康问题和医疗保健用途：队列研究方案

简介 患有炎症性肠病 (IBD) 的人患肺炎和带状疱疹的风险增加，但尚未探索其他常见感染类型。焦虑和抑郁在 IBD 中更为普遍；然而，这些条件对 IBD 中初级保健医疗保健使用的影响尚不清楚。方法和分析 我们将使用基于英国人群的大型初级保健队列进行两项回顾性研究，以比较 IBD 患者和匹配对照组的以下结果：事件感染（研究 1）和普遍的心理健康问题和医疗保健使用，总体和在有或没有精神健康问题的人（研究 2）。所有在 2014 年 1 月 1 日至 2019 年 1 月 1 日期间向皇家全科医师学院研究和监视中心数据库做出贡献的全科医生注册的成年人都有资格。感染结果包括常见感染（上呼吸道感染、肺炎、急性支气管炎、流感和流感样疾病、皮肤感染、单纯疱疹和带状疱疹感染、生殖器感染、尿路感染和胃肠道感染）和任何病毒感染的发生率. 心理健康和医疗保健使用结果是：抑郁发作的流行率；焦虑发作; 复发性抑郁症；初级保健和紧急二级保健就诊率；初级保健机构出具的病假条（反映休假时间）。分析将根据初级保健记录中记录的社会人口因素进行调整。讨论 这些研究将量化 IBD 的感染风险、基于人群的 IBD 队列中焦虑和抑郁的过度负担，以及心理健康状况对医疗保健使用和休假的影响。对感染风险和常见心理健康问题的更多理解和认识将使 IBD 患者和医疗保健从业者受益，并将指导政策制定者，因为资源的分配可能以这些研究产生的真实世界信息为指导。试验注册号 [NCT03836612][1]。数据可能从第三方获得并且不公开可用。RCGP RSC 数据集安全地保存在牛津大学和萨里大学，可供真正的研究人员访问。批准是在逐个项目的基础上进行的 (www.rcgp.org.uk/rsc)。在任何数据发布/其他适当的批准之前，可能需要 NHS 研究伦理委员会的伦理批准。希望直接分析患者级别假名数据的研究人员需要完成信息治理培训并处理来自大学安全服务器的数据。无法从安全网络中取出患者级别的数据。[1]：/lookup/external-ref?link_type=CLINTRIALGOV&access_num=NCT03836612&atom=%2Febmental%2F24%2F2%2F82.atom 希望直接分析患者级别假名数据的研究人员需要完成信息治理培训并处理来自大学安全服务器的数据。无法从安全网络中取出患者级别的数据。[1]：/lookup/external-ref?link_type=CLINTRIALGOV&access_num=NCT03836612&atom=%2Febmental%2F24%2F2%2F82.atom 希望直接分析患者级别假名数据的研究人员需要完成信息治理培训并处理来自大学安全服务器的数据。无法从安全网络中取出患者级别的数据。[1]：/lookup/external-ref?link_type=CLINTRIALGOV&access_num=NCT03836612&atom=%2Febmental%2F24%2F2%2F82.atom