Progressive myoclonus epilepsies (PMEs) are a group of genetic neurological disorders characterised by the occurrence of epileptic seizures, myoclonus and progressive neurological deterioration including cerebellar involvement and dementia. The primary cause of PMEs is variable and alterations in the corresponding mutated genes determine the progression and severity of the disease. In most cases, they lead to the death of the patient after a period of prolonged disability. PMEs also share poor information on the pathophysiological bases and the lack of a specific treatment. Recent reports suggest that neuroinflammation is a common trait under all these conditions. Here, we review similarities and differences in neuroinflammatory response in several PMEs and discuss the window of opportunity of using anti-inflammatory drugs in the treatment of several of these conditions.

中文翻译：

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神经炎症和进行性肌阵挛性癫痫：从基础科学到治疗机会

进行性肌阵挛性癫痫（PMEs）是一组遗传性神经系统疾病，其特征是发生癫痫发作、肌阵挛和进行性神经功能恶化，包括小脑受累和痴呆。PME 的主要原因是可变的，相应突变基因的改变决定了疾病的进展和严重程度。在大多数情况下，它们会导致患者在长期残疾后死亡。PME 还分享了关于病理生理学基础和缺乏特定治疗的不良信息。最近的报告表明，神经炎症是所有这些情况下的共同特征。这里，