当前位置: X-MOL 学术Front. Cell Dev. Biol. › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Extracellular Vesicles: Recent Developments in Aging and Reproductive Diseases
Frontiers in Cell and Developmental Biology ( IF 4.6 ) Pub Date : 2020-08-27 , DOI: 10.3389/fcell.2020.577084
Yu Liu , Qiuzi Shen , Ling Zhang , Wenpei Xiang

Extracellular vesicles (EVs), present in cell culture media and several body fluids, play a prominent role in intercellular communication under physiological and pathological conditions. We performed a systematic literature search to review evidence regarding the existence, composition, and release of different EVs, as well as the biomarkers, cargos, and separation methods. We also reviewed the potential of EVs to transport cargos and alter the function and phenotype of recipient cells associated with aging and reproductive diseases, including polycystic ovary syndrome and endometriosis. In aging, EVs promote inflammatory reactions and offsetting the occurrence of aging. In the polycystic ovary syndrome and endometriosis, EVs and their cargos are involved in the occurrence of diseases, therapeutic strategies, and perform as non-invasive biomarkers. As the study of EVs is still in the early stages, it is not surprising that most of the current literature only describes their possible roles.



中文翻译:

细胞外囊泡:衰老和生殖疾病的最新进展

存在于细胞培养基和几种体液中的细胞外囊泡(EVs)在生理和病理条件下的细胞间通讯中起着重要作用。我们进行了系统的文献检索,以审查有关不同电动汽车的存在,组成和释放以及生物标志物,货物和分离方法的证据。我们还回顾了电动汽车运输货物,改变与衰老和生殖疾病(包括多囊卵巢综合征和子宫内膜异位症)相关的受体细胞的功能和表型的潜力。在老化中,电动汽车会促进炎症反应并抵消老化的发生。在多囊卵巢综合征和子宫内膜异位症中,电动汽车及其货物参与疾病的发生,治疗策略,并作为非侵入性生物标志物发挥作用。

更新日期:2020-09-18
down
wechat
bug