当前位置: X-MOL 学术Viruses › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Functional Characterization of Pepper Vein Banding Virus-Encoded Proteins and Their Interactions: Implications in Potyvirus Infection.
Viruses ( IF 3.8 ) Pub Date : 2020-09-17 , DOI: 10.3390/v12091037
Pallavi Sabharwal 1 , Handanahal S Savithri 1
Affiliation  

Pepper vein banding virus (PVBV) is a distinct species in the Potyvirus genus which infects economically important plants in several parts of India. Like other potyviruses, PVBV encodes multifunctional proteins, with several interaction partners, having implications at different stages of the potyviral infection. In this review, we summarize the functional characterization of different PVBV-encoded proteins with an emphasis on their interaction partners governing the multifunctionality of potyviral proteins. Intrinsically disordered domains/regions of these proteins play an important role in their interactions with other proteins. Deciphering the function of PVBV-encoded proteins and their interactions with cognitive partners will help in understanding the putative mechanisms by which the potyviral proteins are regulated at different stages of the viral life-cycle. This review also discusses PVBV virus-like particles (VLPs) and their potential applications in nanotechnology. Further, virus-like nanoparticle-cell interactions and intracellular fate of PVBV VLPs are also discussed.

中文翻译:

辣椒静脉带状病毒编码蛋白的功能特征及其相互作用:在杯状病毒感染中的意义。

辣椒镶脉病毒(PVBV)是一个独特的物种马铃薯Y病毒属感染印度一些地区的重要经济植物。像其他的杯状病毒一样,PVBV编码具有多个相互作用伙伴的多功能蛋白质,在杯状病毒感染的不同阶段具有影响。在这篇综述中,我们总结了不同PVBV编码蛋白的功能特征,并着重介绍了它们相互作用的伙伴,这些相互作用伙伴控制了杯状病毒蛋白的多功能性。这些蛋白质的内在无序结构域/区域在它们与其他蛋白质的相互作用中起重要作用。破译PVBV编码蛋白的功能及其与认知伴侣的相互作用将有助于理解推定的机制,通过该机制可以在病毒生命周期的不同阶段调节马铃薯病毒蛋白。这篇综述还讨论了PVBV病毒样颗粒(VLP)及其在纳米技术中的潜在应用。此外,还讨论了病毒样纳米粒子-细胞相互作用和PVBV VLP的细胞内命运。
更新日期:2020-09-18
down
wechat
bug