Programmed death ligand-1 (PD-L1) is well known for its role as an immune checkpoint regulator, but little is known about its function in other cellular processes. A study now shows that in tumour cells PD-L1 mediates pyroptosis, an inflammatory form of cell death, by activating the expression of Gasdermine C, ultimately leading to tumour necrosis.

中文翻译：

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PD-L1控制癌症发烧。

程序性死亡配体1（PD-L1）以其作为免疫检查点调节剂的作用而闻名，但对其在其他细胞过程中的功能了解甚少。现在的一项研究表明，PD-L1在肿瘤细胞中通过激活Gasdermine C的表达介导细胞凋亡，这是一种炎性死亡形式，最终导致肿瘤坏死。