Abstract The influence of ibuprofen exposure during the perinatal period, when the brain sexual differentiation process occurs, on the sexual behavior and fertility of female offspring Wistar rats has been evaluated. Ibuprofen was orally administered to the dams at doses of 0, 10, 30 or 60 mg/kg during the gestational (from day 15 to delivery) and lactational period. Females exposed to ibuprofen showed no signs of maternal toxicity. However, ibuprofen provoked a reduction in intrauterine and postnatal growth in female offspring. The treated offspring also showed a decrease in the anogenital distance at birth, while no difference was observed in external signs of the onset of puberty. At adulthood, although the ibuprofen did not interfere with the estrous cyclicity, the lordosis quotient of treated females was reduced. Furthermore, these females presented reduced fertility and low fetal and placenta weights. The females also presented an increase in the percentage of small fetuses and a reduction in the large fetuses for their gestational ages. Perinatal exposure to ibuprofen may interfere with the sexual differentiation of the brain of female offspring of Wistar rats, causing a long-term impact in the sexual behavior and fertility of these females.

中文翻译：

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布洛芬会损害围产期暴露的雌性大鼠的性行为和生育能力

摘要 评估了围产期布洛芬暴露对雌性后代 Wistar 大鼠性行为和生育能力的影响。布洛芬在妊娠期（从第 15 天到分娩）和哺乳期以 0、10、30 或 60 mg/kg 的剂量口服给药。暴露于布洛芬的女性没有表现出母体毒性的迹象。然而，布洛芬导致女性后代的宫内和产后生长减少。接受治疗的后代在出生时也表现出肛门生殖器距离的减少，而青春期开始的外部迹象没有观察到差异。在成年期，虽然布洛芬不会干扰发情周期，但接受治疗的女性的前凸商数降低了。此外，这些女性的生育能力下降，胎儿和胎盘重量低。女性还表现出小胎儿百分比的增加和大胎儿的减少。围产期接触布洛芬可能会干扰 Wistar 大鼠雌性后代大脑的性别分化，对这些雌性大鼠的性行为和生育能力造成长期影响。