Abstract

Introduction

Thrombspondin-1 (TSP-1) is a glycoprotein that has a variety of functions including suppression of angiogenesis and regulation of extracellular matrix deposition. These functions are central to the recovery process after stroke. Data regarding the association and predictive value of TSP-1 and stroke outcomes are limited.

Patients and methods

Patients with ischemic stroke who referred to King Abdullah University Hospital were evaluated for inclusion. The level of serum TSP-1 on admission was assayed using ELISA. Data regarding comorbid diseases as well as stroke severity at baseline, functional outcome and mortality at 6 months were collected prospectively. Favorable outcome was identified as NIHSS or mRS ≤ 1.

Results

Ninety-six patients with an average age of 66.7 years were included. One-third of the patients (32 patients) had favorable outcome on admission. The serum TSP-1 levels in patients with favorable outcome were significantly higher (719.7 vs. 639.9; p = 0.028). Similarly, patients with favorable outcome at 6 months had higher levels of TSP-1 at baseline (714.3 vs. 614.7; p = 0.003). TSP-1 was identified as an independent predictor of favorable outcome at baseline (OR = 0.993, p = 0.038) and after 6 months (OR = 0.99, p = 0.008).

Conclusion

TSP-1 can predict favorable outcomes with regard to the initial severity and long-term functional outcome.

中文翻译：

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评估血小板反应蛋白-1 预测缺血性卒中后卒中结局和死亡率的能力

摘要

介绍

Thrombspondin-1 (TSP-1) 是一种糖蛋白，具有多种功能，包括抑制血管生成和调节细胞外基质沉积。这些功能对于中风后的恢复过程至关重要。关于 TSP-1 和中风结果的关联和预测价值的数据是有限的。

患者和方法

对转诊到阿卜杜拉国王大学医院的缺血性卒中患者进行评估以纳入研究。入院时血清TSP-1水平采用ELISA测定。前瞻性收集了有关合并症以及基线时卒中严重程度、功能结果和 6 个月死亡率的数据。有利的结果被确定为 NIHSS 或 mRS ≤ 1。

结果

纳入平均年龄 66.7 岁的 96 名患者。三分之一的患者（32 名患者）入院时预后良好。预后良好的患者的血清 TSP-1 水平显着升高（719.7 对 639.9；p  = 0.028）。同样，在 6 个月时结果良好的患者在基线时 TSP-1 水平较高（714.3 对 614.7；p  = 0.003）。TSP-1 被确定为基线（OR = 0.993，p  = 0.038）和 6 个月后（OR = 0.99，p  = 0.008）的有利结果的独立预测因子。

结论

TSP-1 可以预测关于初始严重程度和长期功能结果的有利结果。