ABSTRACT

Introduction

Psoriatic Arthritis (PsA) is a multifaceted disease in which various musculoskeletal and skin manifestations are involved. Beyond these features, PsA is associated with comorbidities that might increase the burden of the disease.

Areas covered

In the last years a growing interest has come out for the concept of multimorbidity in rheumatology. Multimorbidity was defined as the ‘co-existence of two or more chronic diseases in the same individual.’ In the multimorbidity concept, the patient is of central concern and all coexisting diseases are of equal importance. Comorbidity was defined as the ‘occurrence of any distinct additional entity during the clinical course of patient who has the index disease under study.’ In PsA, comorbidity and multimorbidity have often been confusingly used interchangeably, showing that there is an unmet need on this topic.

Expert opinion

This perspective article dealt with these different visions of the co-existence of other diseases in PsA, providing a distinction between them, not only for the impact on the treatment decision but also in how this concept might be incorporated into clinical trials design, choosing the right outcome measures for the patient-centric concept of multimorbidity. For this perspective, the authors searched PubMed and the Cochrane library for articles published.

中文翻译：

---

银屑病关节炎的多发病和合并症 - 一个观点。

摘要

介绍

银屑病关节炎 (PsA) 是一种多方面的疾病，其中涉及各种肌肉骨骼和皮肤表现。除了这些特征之外，PsA 还与可能增加疾病负担的合并症有关。

覆盖区域

在过去的几年里，人们对风湿病学中多发病的概念越来越感兴趣。多发病被定义为“同一个体同时存在两种或多种慢性疾病”。在多发病的概念中，患者是核心问题，所有并存疾病同等重要。合并症被定义为“在研究中患有指示疾病的患者的临床过程中出现任何不同的额外实体”。在 PsA 中，合并症和多发病经常被混淆地互换使用，这表明在这个主题上存在未满足的需求。

专家意见

这篇观点文章讨论了 PsA 中其他疾病共存的这些不同观点，提供了它们之间的区别，不仅是对治疗决策的影响，还包括如何将这一概念纳入临床试验设计，选择以患者为中心的多发病概念的正确结果测量。为此，作者在 PubMed 和 Cochrane 图书馆中搜索了已发表的文章。