ABSTRACT

Introduction

In this review, recent developments and applications with cell-penetrating peptides (CPP) are discussed. CPPs are widely used tools for the delivery of various macromolecular therapeutics, such as proteins and nucleic acids.

Areas covered

The current review focuses on recent important advances and reports that demonstrate high clinical and translational potential. Most important clinical developments have occurred with the CPP-drug conjugate approaches that target various protein–protein interactions, and these have been highlighted subsequently. Most of the applications are targeting cancer, but recently, noteworthy advances have taken place in the field of antisense oligonucleotides and muscular dystrophies, lung targeting, and trans-BBB targeting.

Expert opinion

Successful applications and clinical development with the drug conjugate approaches are discussed. On the other hand, the reasons of why the nanoparticle approaches are not as far in development are analyzed.

中文翻译：

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使用细胞穿透肽递送大分子疗法的状态更新

摘要

介绍

在这篇综述中，讨论了细胞穿透肽 (CPP) 的最新发展和应用。CPP 是广泛使用的工具，用于递送各种大分子疗法，例如蛋白质和核酸。

覆盖区域

当前的审查侧重于最近的重要进展和报告，这些进展和报告显示出很高的临床和转化潜力。最重要的临床发展发生在针对各种蛋白质 - 蛋白质相互作用的 CPP-药物偶联物方法，这些已经在随后得到强调。大多数应用都针对癌症，但最近，反义寡核苷酸和肌营养不良症、肺靶向和反式 BBB 靶向领域取得了显着进展。

专家意见

讨论了药物偶联物方法的成功应用和临床开发。另一方面，分析了纳米粒子方法发展不那么远的原因。