Wound healing and tissue regeneration is an intricate biological process that involves repair of cellular damage and maintenance of tissue integrity. Cascades involved in wound healing and tissue regeneration highly overlap with cancer causing pathways. Usually, subsequent tissue damage events include release of a number of cytokines to accomplish post-trauma restoration. IL-22 is one of the cytokines that are immediately produced to initiate immune response against several tissue impairments. IL-22 is a fundamental mediator in inflammation, mucous production, protective role against pathogens, wound healing, and tissue regeneration. However, accumulating evidence suggests pivotal role of IL-22 in instigation of various cancers due to its pro-inflammatory and tissue repairing activity. In this review, we summarize how healing effects of IL-22, when executed in an uncontrollable fashion can lead to carcinogenesis.

伤口愈合和组织再生是一个复杂的生物过程，涉及细胞损伤的修复和组织完整性的维持。涉及伤口愈合和组织再生的级联与致癌途径高度重叠。通常，随后的组织损伤事件包括释放多种细胞因子以实现创伤后恢复。 IL-22 是立即产生的细胞因子之一，可启动针对多种组织损伤的免疫反应。 IL-22 是炎症、粘液生成、针对病原体的保护作用、伤口愈合和组织再生的基本介质。然而，越来越多的证据表明，IL-22 由于其促炎和组织修复活性，在引发各种癌症中发挥着关键作用。在这篇综述中，我们总结了 IL-22 在以不可控方式执行时的治疗作用如何导致癌变。