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Engineering Inorganic Nanoflares with Elaborate Enzymatic Specificity and Efficiency for Versatile Biofilm Eradication.
Small ( IF 13.0 ) Pub Date : 2020-09-17 , DOI: 10.1002/smll.202002348 Meijuan Liang 1 , Yanbing Wang 2 , Kang Ma 1 , Shanshan Yu 1 , Yingying Chen 1 , Zhao Deng 2 , Yi Liu 1 , Fuan Wang 1
Small ( IF 13.0 ) Pub Date : 2020-09-17 , DOI: 10.1002/smll.202002348 Meijuan Liang 1 , Yanbing Wang 2 , Kang Ma 1 , Shanshan Yu 1 , Yingying Chen 1 , Zhao Deng 2 , Yi Liu 1 , Fuan Wang 1
Affiliation
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Nanozyme has emerged as a versatile nanocatalyst yet is constrained with limited catalytic efficiency and specificity for various biomedical applications. Herein, by elaborately integrating the recognition/transduction carbon dots (CDs) with platinum nanoparticles (PtNPs), an exquisite CDs@PtNPs (CPP) nanoflare is engineered as an efficient and substrate‐specific peroxidase‐mimicking nanozyme for high‐performance biosensing and antibacterial applications. The intelligent CPP‐catalyzed hydrogen peroxide (H2O2)‐generated reactive oxygen species realize the sensitive diagnosis‐guided enhanced disinfection of pathogens. Significantly, the CPP nanozyme shows the prominent biofilm eradication and wound healing in vivo by virtue of endogenous H2O2 in acidic infection tissues, which can substantially preclude the annoying antibiotics resistance. A fundamental understanding on the present CPP nanoflare would not only facilitate the advancement of various prospective biocatalysts, but also establish a multifunctional means for versatile biosensing and smart diagnostic applications.
中文翻译：
具有精心设计的酶促特异性和效率的工程无机纳米碎片，可用于多种生物膜的根除。
纳米酶已成为一种通用的纳米催化剂，但受限于各种生物医学应用的有限的催化效率和特异性。在此，通过将识别/转导碳点（CD）与铂纳米颗粒（PtNPs）精心整合在一起，精致的CDs @ PtNPs（CPP）纳米喇叭被设计为一种高效的，底物特异性的过氧化物酶模拟纳米酶，用于高性能生物传感和抗菌应用程序。智能的CPP催化的过氧化氢（H 2 O 2）生成的活性氧可实现敏感的诊断指导下的病原体增强消毒。值得注意的是，CPP纳米酶凭借内源性H 2 O 2在体内具有显着的生物膜根除和伤口愈合的作用。在酸性感染组织中，它可以基本上消除恼人的抗生素耐药性。对当前的CPP纳米闪耀的基本理解不仅将促进各种潜在生物催化剂的发展，而且还将建立一种用于通用生物传感和智能诊断应用的多功能手段。
更新日期：2020-10-16
中文翻译：
具有精心设计的酶促特异性和效率的工程无机纳米碎片，可用于多种生物膜的根除。
纳米酶已成为一种通用的纳米催化剂，但受限于各种生物医学应用的有限的催化效率和特异性。在此，通过将识别/转导碳点（CD）与铂纳米颗粒（PtNPs）精心整合在一起，精致的CDs @ PtNPs（CPP）纳米喇叭被设计为一种高效的，底物特异性的过氧化物酶模拟纳米酶，用于高性能生物传感和抗菌应用程序。智能的CPP催化的过氧化氢（H 2 O 2）生成的活性氧可实现敏感的诊断指导下的病原体增强消毒。值得注意的是，CPP纳米酶凭借内源性H 2 O 2在体内具有显着的生物膜根除和伤口愈合的作用。在酸性感染组织中，它可以基本上消除恼人的抗生素耐药性。对当前的CPP纳米闪耀的基本理解不仅将促进各种潜在生物催化剂的发展，而且还将建立一种用于通用生物传感和智能诊断应用的多功能手段。
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