Due to the widespread antibiotic‐resistant microbes and the slow development in antibiotics, innovative new antibacterial agents are eagerly desired to control infection in the resistance era. Here, it is demonstrated that the antibacterial ability against drug‐resistant bacteria can be endowed to transition metal dichalcogenides (XS₂, X = Mo/W) quantum dots by sulfur vacancies, and their application in bacterial keratitis. The sulfur vacancies are generated by the ion irradiation with the controlled influences, which ensures the one‐way electron transport from the external environment to XS₂ leading to a strong reactive oxygen speciesindependent oxidative stress. With the concentration of 140 µg mL⁻¹ of XS_2–0.1 quantum dots, the sterilization efficiency of Gram‐positive Staphylococcus aureus and methicillin‐resistant Staphylococcus aureus more than 99.9% within 20 min at room temperature in the dark is realized. For biomedical application against bacterial keratitis, it is observed that the occurrence of severe clinical manifestation like ocular perforation can be prevented. This work demonstrates the vacancy as a novel, simple, and effective strategy to tune XS₂ as the antibacterial agent with a fast response and no reliance on light that has significant potential therapeutic effects on clinical drug resistant bacterial keratitis.

中文翻译：

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XS2-y量子点对药物耐药性细菌性角膜炎的空位诱导的抗菌活性。

由于广泛的抗生素耐药性微生物和抗生素的缓慢发展，迫切需要创新的新型抗菌剂来控制耐药性时代的感染。在此证明了，针对硫磺空位的过渡金属二硫代双胍（XS ₂，X = Mo / W）量子点可赋予其对耐药细菌的抗菌能力，并将其应用于细菌性角膜炎。硫空位是由离子辐照在受控的影响下产生的，这确保了单电子从外部环境向XS _2的迁移，从而导致了强烈的反应性氧物种，独立于氧化应激。XS _2–0.1的浓度为140 µg mL ^-1量子点，革兰氏阳性的杀菌效率的金黄色葡萄球菌和耐甲氧西林金黄色葡萄球菌在黑暗中在室温下在99.9％以上在20分钟内实现。对于针对细菌性角膜炎的生物医学应用，已观察到可以防止出现严重的临床表现，如眼穿孔。这项工作证明了该空缺是一种新颖，简单而有效的策略，可将XS ₂作为抗菌剂调整为具有快速反应且不依赖对临床耐药性细菌性角膜炎具有重大潜在治疗作用的光。