Bioimaging: Surface Charge of Supramolecular Nanosystems for In Vivo Biodistribution: A MicroSPECT/CT Imaging Study (Small 37/2020),Small

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Bioimaging: Surface Charge of Supramolecular Nanosystems for In Vivo Biodistribution: A MicroSPECT/CT Imaging Study (Small 37/2020)
Small ( IF 13.0 ) Pub Date : 2020-09-17 , DOI: 10.1002/smll.202070203
Ling Ding _{1,

2} , Zhenbin Lyu _{1,

3} , Beatrice Louis _{4,

5} , Aura Tintaru ₃ , Erik Laurini ₆ , Domenico Marson ₆ , Mengjie Zhang ₇ , Wanxuan Shao ₇ , Yifan Jiang ₁ , Ahlem Bouhlel _{4,

5} , Laure Balasse _{4,

5} , Philippe Garrigue _{4,

5} , Eric Mas ₈ , Suzanne Giorgio ₁ , Juan Iovanna ₈ , Yuanyu Huang ₇ , Sabrina Pricl _{6,

9} , Benjamin Guillet _{4,

5} , Ling Peng ₁

Affiliation

Aix‐Marseille Université CNRS Centre Interdisciplinaire de Nanoscience de Marseille (CINaM), UMR 7325 Equipe Labellisée Ligue Contre le Cancer Marseille 13288 France
Aix‐Marseille Université CNRS Centre de Résonance Magnétique Biologique et Médicale (CRMBM), UMR 7339 Marseille 13385 France
Aix Marseille Univ CNRS Institut de Chimie Radicalaire, UMR 7273 Marseille 13013 France
Aix‐Marseille Université INSERM INRAE, C2VN Marseille 13005 France
Aix‐Marseille Université CNRS CERIMED Marseille 13005 France
Molecular Biology and Nanotechnology Laboratory (MolBNL@UniTS) DEA University of Trieste Trieste 34127 Italy
School of Life Science Advanced Research Institute of Multidisciplinary Science Institute of Engineering Medicine Key Laboratory of Molecular Medicine and Biotherapy Beijing Institute of Technology Beijing 100081 China
Aix‐Marseille Université INSERM CNRS, Institut Paoli‐Calmettes Centre de Recherche en Cancérologie de Marseille (CRCM) Marseille 13288 France
Department of General Biophysics Faculty of Biology and Environmental Protection University of Lodz Lodz 90‐236 Poland

In article number 2003290, Ling Peng and co‐workers report a self‐assembling supramolecular dendrimer probe for tumor imaging by single photon emission computed tomography (SPECT). Altering the radionuclide chelators on the dendrimer surface leads to a highly favorable biodistribution profile with a drastically reduced uptake in liver and a significantly improved tumor imaging contrast.

中文翻译：

生物成像：用于体内生物分布的超分子纳米系统的表面电荷：MicroSPECT / CT成像研究（小型37/2020）

凌鹏及其同事在文章号2003290中报告了一种通过单光子发射计算机断层扫描（SPECT）进行肿瘤成像的自组装超分子树状聚合物探针。改变树枝状聚合物表面上的放射性核素螯合剂可导致高度有利的生物分布特征，并显着降低肝脏的摄取并显着改善肿瘤成像的对比度。

更新日期：2020-09-18

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