This article deals with the synthesis of hybrid nanocomposite hydrogels through the combination of cellulose (C), polypropylene oxide/poly ethylene oxide (PPO/PEO), and silver nanoparticles (AgNPs) by in situ polymerization technique for the in vitro release of ornidazole drugs. The structure of the resulted materials is identified using SEM, XRD, FTIR, XPS, and TGA spectroscopic techniques. The resulting structure, morphology, thermo responsive property, water retention, and swelling behavior of hydrogels are investigated. The rheological measurement is studied to establish the enhancement of the viscoelasticity and stiffness of hydrogels. The antibacterial activity of the biodegradable silver hybrid nanocomposite hydrogel is investigated by inhibition zone method against gram positive and negative bacteria. Maximum drug release of 96.4% is recorded at 7.4 pH in 5 h. The biocompatibility and cytotoxicity of the hybrid nanocomposite hydrogel are verified using mouse fibroblast cell line L‐929 (ATCC CCL‐1) cells for their possible use as controlled drug delivery vehicles. The nontoxic nature makes the materials more biocompatible and suitable to apply in the biological systems. Therefore, nontoxic and biocompatible natures of present materials with improved thermal and rheological properties support for their possible uses as drug delivery vehicles.

中文翻译：

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聚环氧丙烷/聚环氧乙烷-纤维素杂化纳米复合水凝胶作为药物输送载体

本文通过原位聚合技术通过纤维素（C），聚环氧丙烷/聚环氧乙烷（PPO / PEO）和银纳米颗粒（AgNPs）的组合合成杂化纳米复合水凝胶，用于体外释放奥硝唑药物。使用SEM，XRD，FTIR，XPS和TGA光谱技术鉴定所得材料的结构。研究了所得的水凝胶的结构，形态，热响应性，保水性和溶胀行为。研究流变学测量以建立水凝胶的粘弹性和刚度的增强。采用抑菌圈法研究了可生物降解的银杂化纳米复合水凝胶对革兰氏阳性和阴性细菌的抗菌活性。在7.4 pH下，在5小时内记录到96.4％的最大药物释放。使用小鼠成纤维细胞系L-929（ATCC CCL-1）细胞验证了杂合纳米复合水凝胶的生物相容性和细胞毒性，可将其用作受控药物递送载体。无毒性质使材料更具生物相容性，适合用于生物系统。因此，具有改善的热和流变性的本发明材料的无毒和生物相容性支持了它们可能用作药物传递载体。