Chemical synthesis is one of the practical approaches to access carbohydrate‐based natural products and their derivatives with high quality and in a large quantity. However, stereoselectivity during the glycosylation reaction is the main challenge because the reaction can generate both α‐ and β‐glycosides. The main focus of the present article is the concept of recent mechanistic studies that have applied statistical analysis and quantitation for defining stereoselective changes during the reaction process. Based on experimental evidence, a detailed discussion associated with the mechanism and degree of influence affecting the stereoselective outcome of glycosylation is included.

中文翻译：

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糖基化反应的统计分析

化学合成是获取大量基于碳水化合物的天然产物及其衍生物的实用方法之一。但是，糖基化反应期间的立体选择性是主要挑战，因为该反应可同时产生α-和β-糖苷。本文的主要重点是最近的力学研究的概念，这些研究已应用统计分析和定量来定义反应过程中的立体选择性变化。基于实验证据，包括与影响糖基化的立体选择性结果的机制和影响程度有关的详细讨论。