Clusterin suppresses spermatogenic cell apoptosis to alleviate diabetes‐induced testicular damage by inhibiting autophagy via the PI3K/AKT/mTOR axis,Biology of the Cell

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Clusterin suppresses spermatogenic cell apoptosis to alleviate diabetes‐induced testicular damage by inhibiting autophagy via the PI3K/AKT/mTOR axis
Biology of the Cell ( IF 2.4 ) Pub Date : 2020-11-04 , DOI: 10.1111/boc.202000030
Yuan Tian _{1,

2} , Yue-Hai Xiao ₂ , Tian Geng ₁ , Chao Sun ₁ , Jiang Gu _{1,

2} , Kai-Fa Tang _{1,

2} , Bei Liu ₁ , Yi-Meng Liu ₃ , Fa Sun _{4,

5}

Affiliation

Diabetes‐induced testicular dysfunction is characterised by abnormal apoptosis of spermatogenic cells, but the underlying mechanism is poorly understood. This study aimed to investigate the roles of clusterin (CLU) in testicular damage associated with diabetes pathogenesis, as well as the molecular mechanism.

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