Thromboembolic and infectious complications stemming from the use of cardiovascular medical devices are still common and result in significant morbidity and mortality. There is no strategy to date that effectively addresses both challenges at the same time. Various surface modification strategies (e.g., silver, heparin, and liquid‐impregnated surfaces) are proposed yet each has several limitations and shortcomings. Here, it is shown that the incorporation of an ultrathin and mechanically robust hydrogel layer reduces bacterial adhesion to medical‐grade tubing by 95%. It is additionally demonstrated, through a combination of in vitro and in vivo tests, that the hydrogel layer significantly reduces the formation and adhesion of blood clots to the tubing without affecting the blood's intrinsic clotting ability. The adhesion of clots to the tubing walls is reduced by over 90% (in vitro model), which results in an ≈60% increase in the device occlusion time (time before closure due to clot formation) in an in vivo porcine model. The advantageous properties of this passive coating make it a promising surface material candidate for medical devices interfacing with blood.

中文翻译：

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心血管医疗设备上的超薄且坚固的水凝胶涂层，可减轻血栓栓塞性和感染性并发症。

由于使用心血管医疗设备而引起的血栓栓塞性和感染性并发症仍然很常见，并导致明显的发病率和死亡率。迄今为止，还没有策略可以有效地同时解决这两个挑战。提出了各种表面改性策略（例如，银，肝素和液体浸渍表面），但每种策略都有一些局限性和不足。在这里，表明超薄和机械坚固的水凝胶层的结合使细菌与医用级管道的附着力降低了95％。另外，通过体外和体内试验的结合，证明了水凝胶层显着减少了血凝块对管道的形成和粘附，而不会影响血液的固有凝结能力。凝块在管壁上的粘附减少了90％以上（体外模型），这导致体内猪模型中的装置阻塞时间（由于凝块形成而导致闭合之前的时间）增加了约60％。这种无源涂层的有利性能使其成为有希望的表面材料，可用于与血液接口的医疗设备。