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Review of Integrin-Targeting Biomaterials in Tissue Engineering.
Advanced Healthcare Materials ( IF 10.0 ) Pub Date : 2020-09-16 , DOI: 10.1002/adhm.202000795 Prachi Dhavalikar 1 , Andrew Robinson 1 , Ziyang Lan 1 , Dana Jenkins 1 , Malgorzata Chwatko 1 , Karim Salhadar 1 , Anupriya Jose 1 , Ronit Kar 1 , Erik Shoga 1 , Aparajith Kannapiran 1 , Elizabeth Cosgriff-Hernandez 1
Advanced Healthcare Materials ( IF 10.0 ) Pub Date : 2020-09-16 , DOI: 10.1002/adhm.202000795 Prachi Dhavalikar 1 , Andrew Robinson 1 , Ziyang Lan 1 , Dana Jenkins 1 , Malgorzata Chwatko 1 , Karim Salhadar 1 , Anupriya Jose 1 , Ronit Kar 1 , Erik Shoga 1 , Aparajith Kannapiran 1 , Elizabeth Cosgriff-Hernandez 1
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The ability to direct cell behavior has been central to the success of numerous therapeutics to regenerate tissue or facilitate device integration. Biomaterial scientists are challenged to understand and modulate the interactions of biomaterials with biological systems in order to achieve effective tissue repair. One key area of research investigates the use of extracellular matrix‐derived ligands to target specific integrin interactions and induce cellular responses, such as increased cell migration, proliferation, and differentiation of mesenchymal stem cells. These integrin‐targeting proteins and peptides have been implemented in a variety of different polymeric scaffolds and devices to enhance tissue regeneration and integration. This review first presents an overview of integrin‐mediated cellular processes that have been identified in angiogenesis, wound healing, and bone regeneration. Then, research utilizing biomaterials are highlighted with integrin‐targeting motifs as a means to direct these cellular processes to enhance tissue regeneration. In addition to providing improved materials for tissue repair and device integration, these innovative biomaterials provide new tools to probe the complex processes of tissue remodeling in order to enhance the rational design of biomaterial scaffolds and guide tissue regeneration strategies.
中文翻译：
组织工程中整合素靶向生物材料的综述。
指导细胞行为的能力对于许多组织再生或促进设备集成的治疗方法的成功至关重要。生物材料科学家面临的挑战是理解和调节生物材料与生物系统的相互作用，以实现有效的组织修复。研究的一个关键领域是利用细胞外基质衍生的配体来靶向特定的整合素相互作用并诱导细胞反应，例如增加间充质干细胞的细胞迁移、增殖和分化。这些整合素靶向蛋白和肽已应用于各种不同的聚合物支架和装置中，以增强组织再生和整合。本综述首先概述了在血管生成、伤口愈合和骨再生中已发现的整合素介导的细胞过程。然后，利用生物材料的研究以整合素靶向基序为重点，作为指导这些细胞过程以增强组织再生的手段。除了为组织修复和设备集成提供改进的材料外，这些创新的生物材料还提供了新的工具来探索组织重塑的复杂过程，以增强生物材料支架的合理设计并指导组织再生策略。
更新日期：2020-09-16
中文翻译：
组织工程中整合素靶向生物材料的综述。
指导细胞行为的能力对于许多组织再生或促进设备集成的治疗方法的成功至关重要。生物材料科学家面临的挑战是理解和调节生物材料与生物系统的相互作用，以实现有效的组织修复。研究的一个关键领域是利用细胞外基质衍生的配体来靶向特定的整合素相互作用并诱导细胞反应，例如增加间充质干细胞的细胞迁移、增殖和分化。这些整合素靶向蛋白和肽已应用于各种不同的聚合物支架和装置中，以增强组织再生和整合。本综述首先概述了在血管生成、伤口愈合和骨再生中已发现的整合素介导的细胞过程。然后，利用生物材料的研究以整合素靶向基序为重点，作为指导这些细胞过程以增强组织再生的手段。除了为组织修复和设备集成提供改进的材料外，这些创新的生物材料还提供了新的工具来探索组织重塑的复杂过程，以增强生物材料支架的合理设计并指导组织再生策略。
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