Polymeric Hydrogel Systems as Emerging Biomaterial Platforms to Enable Hemostasis and Wound Healing.,Advanced Healthcare Materials

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Polymeric Hydrogel Systems as Emerging Biomaterial Platforms to Enable Hemostasis and Wound Healing.
Advanced Healthcare Materials ( IF 10.0 ) Pub Date : 2020-09-16 , DOI: 10.1002/adhm.202000905
Sara Pourshahrestani ₁ , Ehsan Zeimaran ₁ , Nahrizul Adib Kadri ₁ , Nurshen Mutlu ₂ , Aldo R Boccaccini ₃

Affiliation

Broad interest in developing new hemostatic technologies arises from unmet needs in mitigating uncontrolled hemorrhage in emergency, surgical, and battlefield settings. Although a variety of hemostats, sealants, and adhesives are available, development of ideal hemostatic compositions that offer a range of remarkable properties including capability to effectively and immediately manage bleeding, excellent mechanical properties, biocompatibility, biodegradability, antibacterial effect, and strong tissue adhesion properties, under wet and dynamic conditions, still remains a challenge. Benefiting from tunable mechanical properties, high porosity, biocompatibility, injectability and ease of handling, polymeric hydrogels with outstanding hemostatic properties have been receiving increasing attention over the past several years. In this review, after shedding light on hemostasis and wound healing processes, the most recent progresses in hydrogel systems engineered from natural and synthetic polymers for hemostatic applications are discussed based on a comprehensive literature review. Most studies described used in vivo models with accessible and compressible wounds to assess the hemostatic performance of hydrogels. The challenges that need to be tackled to accelerate the translation of these novel hemostatic hydrogel systems to clinical practice are emphasized and future directions for research in the field are presented.

中文翻译：

聚合物水凝胶系统作为新兴的生物材料平台，可实现止血和伤口愈合。

对开发新的止血技术的广泛兴趣来自缓解紧急情况，外科手术和战场环境中无法控制的出血的未满足需求。尽管可以使用各种止血剂，密封剂和粘合剂，但是理想的止血组合物的开发提供了一系列显着的性能，包括有效且立即处理出血的能力，出色的机械性能，生物相容性，生物降解性，抗菌作用以及强大的组织粘附性能在潮湿和动态条件下，仍然是一个挑战。得益于可调节的机械性能，高孔隙率，生物相容性，可注射性和易于处理，具有出色止血性能的聚合物水凝胶在过去几年中受到越来越多的关注。在这篇评论中在阐明止血和伤口愈合过程之后，基于全面的文献综述，讨论了由天然和合成聚合物制成的用于止血应用的水凝胶系统的最新进展。大多数研究描述了在体内使用具有可及及可压缩伤口的模型来评估水凝胶的止血性能。强调了加速将这些新型止血水凝胶系统转化为临床实践所需要解决的挑战，并提出了该领域研究的未来方向。大多数研究描述了在体内使用具有可及及可压缩伤口的模型来评估水凝胶的止血性能。强调了加速将这些新型止血水凝胶系统转化为临床实践所需要解决的挑战，并提出了该领域研究的未来方向。大多数研究描述了在体内使用具有可及及可压缩伤口的模型来评估水凝胶的止血性能。强调了加速将这些新型止血水凝胶系统转化为临床实践所需要解决的挑战，并提出了该领域研究的未来方向。

更新日期：2020-10-22

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