The repair of a cartilage lesion with a hydrogel requires a method for long‐term fixation of the hydrogel in the defect site. Attachment of a hydrogel to a base that allows for integration with bone can enable long‐term fixation of the hydrogel, but current methods of forming bonds to hydrogels have less than a tenth of the shear strength of the osteochondral junction. This communication describes a new method, nanofiber‐enhanced sticking (NEST), for bonding a hydrogel to a base with an adhesive shear strength three times larger than the state‐of‐the‐art. An example of NEST is described in which a nanofibrous bacterial cellulose sheet is bonded to a porous base with a hydroxyapatite‐forming cement followed by infiltration of the nanofibrous sheet with hydrogel‐forming polymeric materials. This approach creates a mineralized nanofiber bond that mimics the structure of the osteochondral junction, in which collagen nanofibers extend from cartilage into a mineralized region that anchors cartilage to bone.

中文翻译：

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通过纳米纤维增强的高强度水凝胶附着

用水凝胶修复软骨病变需要一种将水凝胶长期固定在缺损部位的方法。将水凝胶附着在可以与骨骼整合的基底上可以使水凝胶长期固定，但是目前与水凝胶形成键的方法的强度不到骨软骨交界处的剪切强度的十分之一。本通讯介绍了一种新的方法，即纳米纤维增强粘合（NEST），用于将水凝胶粘合到基体上，其粘合剪切强度是最新技术的三倍。以NEST为例，其中将纳米纤维细菌纤维素片材与形成羟基磷灰石的胶粘剂粘结到多孔基底上，然后用形成水凝胶的聚合材料渗透纳米纤维片材。