The Intersection of Mechanotransduction and Regenerative Osteogenic Materials.,Advanced Healthcare Materials

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The Intersection of Mechanotransduction and Regenerative Osteogenic Materials.
Advanced Healthcare Materials ( IF 10.0 ) Pub Date : 2020-09-16 , DOI: 10.1002/adhm.202000709
Anthony A Bertrand ₁ , Sri Harshini Malapati ₁ , Dean T Yamaguchi _{1,

2} , Justine C Lee _{1,

2,

3}

Affiliation

Mechanical signals play a central role in cell fate determination and differentiation in both physiologic and pathologic circumstances. Such signals may be delivered using materials to generate discrete microenvironments for the purposes of tissue regeneration and have garnered increasing attention in recent years. Unlike the addition of progenitor cells or growth factors, delivery of a microenvironment is particularly attractive in that it may reduce the known untoward consequences of the former two strategies, such as excessive proliferation and potential malignant transformation. Additionally, the ability to spatially modulate the fabrication of materials allows for the creation of multiple microenvironments, particularly attractive for regenerating complex tissues. While many regenerative materials have been developed and tested for augmentation of specific cellular responses, the intersection between cell biology and material interactions have been difficult to dissect due to the complexity of both physical and chemical interactions. Specifically, modulating materials to target individual signaling pathways is an avenue of interdisciplinary research that may lead to a more effective method of optimizing regenerative materials. In this work, the aim is to summarize the major mechanotransduction pathways for osteogenic differentiation and to consolidate the known materials and material properties that activate such pathways.

中文翻译：

力转导和再生成骨材料的交叉点。

机械信号在生理和病理情况下的细胞命运决定和分化中发挥着核心作用。此类信号可以使用材料来传递以产生离散的微环境以达到组织再生的目的，并且近年来引起了越来越多的关注。与添加祖细胞或生长因子不同，微环境的传递特别有吸引力，因为它可以减少前两种策略已知的不良后果，例如过度增殖和潜在的恶性转化。此外，空间调节材料制造的能力允许创建多个微环境，这对于再生复杂组织特别有吸引力。虽然许多再生材料已被开发和测试用于增强特定的细胞反应，但由于物理和化学相互作用的复杂性，细胞生物学和材料相互作用之间的交叉点很难剖析。具体来说，调节材料以靶向单个信号通路是跨学科研究的一个途径，可能会带来更有效的优化再生材料的方法。在这项工作中，目的是总结成骨分化的主要机械转导途径，并巩固激活这些途径的已知材料和材料特性。

更新日期：2020-10-22

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