Highly Stretchable Metal–Polymer Conductor Electrode Array for Electrophysiology,Advanced Healthcare Materials

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Highly Stretchable Metal–Polymer Conductor Electrode Array for Electrophysiology
Advanced Healthcare Materials ( IF 10.0 ) Pub Date : 2020-09-16 , DOI: 10.1002/adhm.202000641
Ruihua Dong _{1,

2} , Xiaoyan Liu ₃ , Shiyu Cheng ₂ , Lixue Tang ₃ , Mian Chen ₂ , Leni Zhong ₂ , Zhen Chen ₂ , Shaoqin Liu ₁ , Xingyu Jiang _{1,

2,

3}

Affiliation

Narrowing the mechanical mismatch between biological tissues (typically soft) and neural interfaces (hard) is essential for maintaining signal quality for the electrical recording of neural activity. However, only a few materials can satisfy all requirements for such electronics, which need to be both biocompatible and sufficiently soft. Here, a highly stretchable electrode array (SEA) is introduced, based on the liquid metal–polymer conductor (MPC), achieving high mechanical flexibility and good cytocompatability for neural interfaces. By utilizing the MPC, the SEA exhibits high stretchability (≈100%) and excellent cycling stability (>400 cycles). The cytocompatability of the SEA can allow for long‐term culturing of primary neurons and enable signal recording of primary hippocampal neurons. In the future, the SEA could serve as a reliable and robust platform for diagnostics in neuronal tissues and greatly advance brain–machine interfaces.

中文翻译：

用于电生理学的高拉伸性金属-聚合物导体电极阵列

缩小生物组织（通常是软组织）和神经接口（硬组织）之间的机械失配，对于维持神经活动的电记录信号质量至关重要。但是，只有很少的材料可以满足此类电子设备的所有要求，既需要生物相容又要足够柔软。在此，基于液态金属-聚合物导体（MPC）引入了高度可拉伸的电极阵列（SEA），实现了较高的机械柔韧性和良好的神经界面细胞相容性。通过使用MPC，SEA表现出高拉伸性（≈100％）和出色的循环稳定性（> 400个循环）。SEA的细胞相容性可以长期培养原代神经元，并可以记录原代海马神经元的信号。将来，

更新日期：2020-09-16

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