Venous thrombosis is a life-threatening condition with high morbidity and mortality. Abnormal functioning of different cells in the blood is an integral part of its pathogenesis. In this review, we describe the contribution of bone marrow-derived cells to the development of this debilitating disease. We present both epidemiological and clinical data demonstrating involvement of various cell types in venous thrombosis, and discuss potential mechanisms underlying these effects. Modern concepts including recently discovered new paradigms in thrombosis, such as neutrophil extracellular traps, mast cells, and polyphosphate, are summarized.

中文翻译：

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骨髓源性细胞在静脉血栓栓塞中的作用。

静脉血栓形成是一种危及生命的疾病，发病率和死亡率都很高。血液中不同细胞的功能异常是其发病机制的一个组成部分。在这篇综述中，我们描述了骨髓衍生细胞对这种使人衰弱的疾病的发展的贡献。我们提供流行病学和临床数据，证明各种细胞类型参与静脉血栓形成，并讨论这些影响的潜在机制。总结了现代概念，包括最近发现的血栓形成新范式，例如中性粒细胞胞外陷阱、肥大细胞和多磷酸盐。