Two new compounds, named carpabrotalactone C (1) and methyl 8-[2(5H)-furanon-5-yl]octanoate (2), were isolated from the herbs of Carpesium abrotanoides L. The structures of these compounds were elucidated based on spectroscopic analysis, single crystal X-ray diffraction analysis and ECD calculation. Compound 1 exhibited potent cytotoxicity against the A549, SMMC-7721, MCF-7 and SW480 cell lines, with IC₅₀ values from 11.46 to 23.68 μM. Meantime, compound 1 showed weak inhibitory eff ;ects on LPS-induced NO release in RAW 264.7 cell lines, with IC₅₀ value of 63.23 ± 2.55 μM.

中文翻译：

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两种从阿布罗地那酸Carpesium的新化合物

从阿布罗地那酸Carpesium L.的草药中分离了两种新化合物，分别为carbabrotalactone C（1）和8- [2（5 H）-呋喃基-5-基]辛酸甲酯（2）。这些化合物的结构基于光谱分析，单晶X射线衍射分析和ECD计算。化合物1对A549，SMMC-7721，MCF-7和SW480细胞系表现出强大的细胞毒性，IC ₅₀值为11.46至23.68μM。同时，化合物1对RAW 264.7细胞系中LPS诱导的NO释放表现出微弱的抑制作用，IC ₅₀值为63.23±2.55μM。