PARP enzymes are increasingly taking on important roles beyond DNA repair. Huang et al. (2020b) report how the NAD⁺-dependent ADP-ribosylation of histone H2B by PARP-1 in complex with a metabolic enzyme suppresses the phosphorylation of an adjacent residue, impacting adipogenesis.

中文翻译：

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PARP-1会导致肥胖的表观遗传转换。

PARP酶越来越起着DNA修复以外的重要作用。黄等。（2020b）报告了PARP-1与代谢酶复合后，组蛋白H2B的NAD ⁺依赖性ADP核糖基化如何抑制相邻残基的磷酸化，从而影响脂肪形成。