Two experiments were conducted to (1) investigate the effects of different doses of dihydroartemisinin (DiHA) on growth performance, nutrient digestibility, serum biochemistry, antioxidant and immune function in weaned piglets and determine the optimal dose of DiHA and (2) investigate the effects of DiHA on growth, intestinal digestive function and nutrient transporters in weaned piglets with intrauterine growth retardation (IUGR). In experiment 1, a total of 360 21-day-old weaned piglets were randomly allocated into six dietary treatments, including control group (basal diet), DiHA 20, DiHA 40, DiHA 80, DiHA 160 and DiHA 320 groups (basal diet supplemented with 20, 40, 80, 160, 320 mg/kg DiHA, respectively). At 42 days of age, a digestibility trial was conducted for 7 days. At 49 days of age, the growth performance, serum biochemistry, antioxidant and immune function were measured. The results showed that DiHA at the dose of 80 mg/kg significantly improved (P < 0.05) growth performance and decreased the incidence of diarrhea. Diet supplemented with 80 mg/kg DiHA also improved (P < 0.05) the nutrient digestibility, ameliorated serum biochemistry and improved serum cytokine levels. Therefore, according to these results, the optimal dose of DiHA in pig diet was considered to be 80 mg/kg. In experiment 2, weaned piglets (21 d) with normal birth weight (NBW) and IUGR fed the basal diet (NBW-CON and IUGR-CON groups) or the 80 mg/kg DiHA diet (IUGR-DiHA group) for 4 wk. Compared with NBW piglets, IUGR piglets decreased (P < 0.05) body weight at 0, 7, 14, 21 days of age and average daily gain (ADG) during 0–7 d, 7–14 d, and 0–21 d period as well as ADG and average daily feed intake (ADFI) at 49 days of age. IUGR led to the impaired development of intestine, decreased activities of intestinal digestive enzyme and disaccharidase, reduced concentrations of glucose transporter and mRNA expressions of related nutrient transporters in weaned piglets. After treatment with DiHA in IUGR piglets, ADG and ADFI, the relative weight of jejunum, the activities of ileal amylase and trypsin, the activities of jejunal lactase, maltase and alkaline phosphatase, the concentrations of jejunal glucose transporter 2 and ileal sodium-dependent glucose transporter 1, and mRNA expressions of nutrient transporters were improved (P < 0.05). In conclusion, 80 mg/kg DiHA in the diet has beneficial effects in improving the development of small intestine and alleviating the impairment of nutrient digestion and transporters in IUGR weaned piglets.

进行了两个实验，以（1）研究不同剂量的双氢青蒿素（DiHA）对断奶仔猪生长性能，养分消化率，血清生化，抗氧化剂和免疫功能的影响，并确定DiHA的最佳剂量；（2）研究其作用。对胎儿宫内发育迟缓（IUGR）断奶仔猪生长，肠道消化功能和营养转运的影响 在实验1中，总共将360只21天大的断奶仔猪随机分为6种饮食处理，包括对照组（基础饮食），DiHA 20，DiHA 40，DiHA 80，DiHA 160和DiHA 320组（补充基础饮食）分别添加20、40、80、160、320 mg / kg DiHA）。在42日龄时，进行了7天的消化率试验。在49日龄时，其生长表现，血清生化，测定抗氧化和免疫功能。结果表明，DiHA的剂量为80 mg / kg明显改善（P <0.05）的生长性能和减少腹泻的发生率。补充80 mg / kg DiHA的饮食还改善了营养消化率（P <0.05），改善了血清生物化学，并改善了血清细胞因子水平。因此，根据这些结果，猪饲料中DiHA的最佳剂量被认为是80 mg / kg。在实验2中，出生体重正常（NBW）的断奶仔猪（21 d）和IUGR饲喂基础饮食（NBW-CON和IUGR-CON组）或80 mg / kg DiHA饮食（IUGR-DiHA组）4周。与NBW仔猪相比，IUGR仔猪减少了（P<0.05）0、7、14、21日龄时的体重和0-7 d，7-14 d和0-21 d期间的日平均增重（ADG）以及ADG和日平均采食量（ ADFI），年龄为49天。IUGR导致断奶仔猪肠道发育受损，肠道消化酶和二糖苷酶活性降低，葡萄糖转运蛋白浓度降低以及相关营养物质转运蛋白的mRNA表达。在IUGR仔猪，ADG和ADFI中用DiHA处理后，空肠的相对重量，回肠淀粉酶和胰蛋白酶的活性，空肠乳糖酶，麦芽糖酶和碱性磷酸酶的活性，空肠葡萄糖转运蛋白2的浓度和回肠钠依赖性葡萄糖转运蛋白1，营养转运蛋白的mRNA表达得到改善（P<0.05）。总之，日粮中的80 mg / kg DiHA对改善IUGR断奶仔猪的小肠发育和减轻营养物质消化和转运蛋白的损害具有有益作用。