Pickering emulsions are surfactant-free emulsions stabilized by solid particles. Their unique structure endows them with good stability, excellent biocompatibility, and environmental friendliness. Pickering emulsions have displayed great potential in oral drug delivery. Several-fold increases in the oral bioavailability or bioaccessibility of poorly soluble drugs, such as curcumin, silybin, puerarin, and rutin, were achieved by using Pickering emulsions, whereas controlled release was found for indomethacin and caffeine. The shell of the interfacial particle stabilizers provides enhanced gastrointestinal stability to the cargos in the oil core. Here, we also discuss general considerations concerning particle stabilizers and design strategies to control lipid digestion.

Pickering 乳液是由固体颗粒稳定的不含表面活性剂的乳液。其独特的结构赋予其良好的稳定性、优异的生物相容性和环境友好性。 Pickering乳液在口服药物递送方面显示出巨大的潜力。通过使用皮克林乳剂，难溶性药物（例如姜黄素、水飞蓟宾、葛根素和芦丁）的口服生物利用度或生物可及性增加了几倍，而吲哚美辛和咖啡因则发现了控释。界面颗粒稳定剂的壳为油核中的货物提供增强的胃肠道稳定性。在这里，我们还讨论了有关颗粒稳定剂的一般考虑因素和控制脂质消化的设计策略。