Mammalian cryptochromes regulate sleep and metabolism as components of the circadian clock. In this issue of Cell Chemical Biology, Miller et al. (2020a) use phenotypic chemical screens to identify selective modulators of two cryptochrome isoforms. Binding specificity depends on conformational patterning of the ligand-binding pocket and a disordered C-terminal domain.

中文翻译：

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结束：有选择地给隐花色素的混杂口袋下药会减慢昼夜节律。

哺乳动物隐花色素作为生物钟的组成部分调节睡眠和新陈代谢。在本期《细胞化学生物学》中，Miller 等人。(2020a) 使用表型化学筛选来识别两种隐花色素同种型的选择性调节剂。结合特异性取决于配体结合口袋的构象模式和无序的 C 端结构域。