Cyclic-3′,5′-adenosine monophosphate (cAMP) is an ancient second messenger but organizing signaling selectivity on the nanoscale is poorly understood. Examining transport of a new fluorescent cAMP probe, Bock and coworkers observe “buffered diffusion” and establish phosphodiesterase activity can organize cAMP nanodomains, while Zhao and coworkers find that protein kinase A regulatory subunits assemble liquid droplets to further localize cAMP signaling.

中文翻译：

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纳米域中的cAMP信号传导。

环3'，5'-单磷酸腺苷（cAMP）是古老的第二信使，但在纳米级组织信号选择性的了解却很少。在检查新型荧光cAMP探针的运输过程中，Bock和同事观察到“缓冲扩散”并建立磷酸二酯酶活性可以组织cAMP纳米域，而Zhao和同事发现蛋白激酶A调节亚基组装液滴以进一步定位cAMP信号传导。